Penciclovir is a synthetic acyclic guanine derivative with antiviral activity, mainly used to treat infections from herpes simplex virus (HSV) types 1 and 2. In HSV infected cells, penciclovir is phosphorylated by viral thymidine kinase and subsequently converted by cellular kinases into the active metabolite, penciclovir triphosphate, which competitively inhibits viral HSV polymerase by blocking deoxyguanosine triphosphate substrate binding[3]. Penciclovir are phosphorylated by viral thymidine kinase and are incorporated into the DNA chain by viral DNA polymerase, resulting in chain termination[4]. Penciclovir pharmacokinetics following oral administration of famciclovir were nonlinear within the dosage range studied, likely because of saturation of famciclovir metabolism. Oral administration of famciclovir at 40 or 90 mg/kg produced similar C(max) and time to C(max) values. Therefore, the lower dose may have similar antiviral efficacy to that proven for the higher dose[5]. Oral administration of 40 mg of famciclovir/kg to cats resulted in a tear penciclovir concentration-time profile that approximated the plasma penciclovir concentration-time profile and frequently achieved a penciclovir concentration at the ocular surface likely to be effective against FHV-1(feline herpesvirus) [6].
United States, California
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Women's Health Care at Frost Street
San Diego, California, United States
United States, Illinois
Children's Memorial Hospital
Chicago, Illinois, United States, 60614
United States, Indiana
Medisphere Medical Research Center, LLC
Evansville, Indiana, United States, 47714
United States, Missouri
Clayton Medical Research
St. Louis, Missouri, United States, 63117
United States, New York
Rochester Clinical Research, Inc.
Rochester, New York, United States
United States, Ohio
Cincinnati Children's Hospital Medical Center
Cincinnati, Ohio, United States, 45229
University Hospitals Case Medical Center
Cleveland, Ohio, United States, 44106
United States, Oregon
Westover Heights Clinic
Portland, Oregon, United States, 97210
United States, Pennsylvania
Primary Physicians Research, Inc
Pittsburgh, Pennsylvania, United States
United States, Texas
Texas Children's Hospital
Houston, Texas, United States, 77030
R/D Clinical Research, Inc
Lake Jackson, Texas, United States, 77566
R/D Clinical Research
Lake Jackson, Texas, United States, 77566 收起 <<
United States, Alabama
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University of Alabama at Birmingham
Birmingham, Alabama, United States, 35233-1711
United States, Colorado
The Children's Hospital
Denver, Colorado, United States, 80218
United States, Illinois
Children's Memorial Hospital
Chicago, Illinois, United States, 60614
United States, Kentucky
Kosair Charities Pediatric Clinical Research Unit
Louisville, Kentucky, United States, 40202-3830
United States, New York
Columbia University Medical Center
New York, New York, United States, 10032
State University of New York at
Stony Brook, New York, United States, 11794-3362
United States, North Carolina
Duke University Medical Center
Durham, North Carolina, United States, 27710
United States, Ohio
Cincinnati Children's Hospital Medical Center
Cincinnati, Ohio, United States, 45229-3039
University Hospitals of Cleveland
Cleveland, Ohio, United States, 44106
United States, Texas
Children's Medical Center of Dallas
Dallas, Texas, United States, 75235
Baylor College of Medicine/Texas Children's Hospital
Houston, Texas, United States, 77030
Panama
Panama Minister of Health
Ciudad de David, Chiriqui, Panama
Panama Minister of Health
Ciudad de Panama, Panama 收起 <<
United States, New York
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Weill Cornell Medicine
Recruiting
New York, New York, United States, 10065
Contact: Eileen Chang 212-746-6248 eic2002@med.cornell.edu
Contact: Jamie Stern (212) 746-9748
Principal Investigator: Alexander Shtilbans, MD 收起 <<
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