Patchouli alcohol (PA) is a natural tricyclic sesquiterpene extracted from Pogostemon cablin (Blanco) Benth, and exhibits anti-Helicobacter pylori and anti-inflammatory properties. Treatment with PA for 2 weeks exhibited highly efficient protective effect against H. pylori-induced gastritis and related damages[3]. PA ameliorated DSS-induced (dextran sulfate sodium) mice acute colitis by suppressing inflammation, maintaining the integrity of intestinal epithelial barrier, inhibiting cell death signaling, and suppressing tryptophan catabolism[4]. Treatment of patchouli alcohol reduced lipid accumulation in 3T3-L1 adipocytes in a dose-dependent manner without toxicity. Oral gavage of patchouli alcohol led to a significant reduction of body weight and fat accumulation in the mice fed with HFD (high-fat diet)[5]. PA significantly inhibited different IAV (anti-influenza virus) strains multiplication in vitro, and may block IAV infection through inactivating virus particles directly and interfering with some early stages after virus adsorption[6].
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