Paromomycin sulfate is a derivative of neomycin, is a broad-spectrum aminoglycoside antibiotic noted for its amebicidal and bactericidal properties. It binds specifically to the RNA oligonucleotide at the A site of bacterial 30S ribosomes, leading to premature termination of mRNA translation and inhibition of protein synthesis. This makes paromomycin sulfate suitable for research on bacterial and parasitic infections[1].[2].[3].
体内研究
When administered via oral gavage at doses ranging from 50 mg/kg to 200 mg/kg daily for five consecutive days, starting two weeks post-infection, paromomycin sulfate significantly reduces the count of oocysts per gram of feces and in the intestines. Histological examination reveals minimal focal inflammation in only 20% of intestinal sections from mice infected with C. parvum at a dose of 50 mg/kg and only 10% focal inflammation at 200 mg/kg, indicating its efficacy and relative safety at these dosages[1].
体外研究
In cell culture studies, paromomycin sulfate at a concentration of 500 μg/ml dramatically reduces intracellular parasitic forms by 97.2% in Caco-2 cells and by 99.5% in HCT-8 cells relative to control, demonstrating its effectiveness against intracellular parasites[2].
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