Panaxatriol, a natural product isolated and purified from the roots of Panax ginseng C. A. Mey. with significant antiradiation effects by reducing the frequency of chromatid mutative induced by X-ray, ameliorates I/R-induced myocardial damage by reducing oxidative stress, relieves myelosuppression induced by radiation injury ,via regulating the expression of hemopoietic growth factor GM-CSF, and has protective effects on the focal cerebral ischemia of MACO (middle cerebral artery occlusion) rats or incompleted global brain ischemia mice.
3. Panaxatriol may
Panaxatriol is a natural product. Panaxatriol (200 mg/kg/d, 3 weeks) can relieve myelosuppression induced by radiation injury[3]. Panaxatriol exerts dosedependent cytotoxic effects on prostate DU-15 cancer cells. The IC50 of panaxatriol was 30 μM. Additionally, panaxatriol induced sub-G1 cell cycle arrest and suppressed the DU-15 cell migration ability in a concentration-dependent manner[4]. PT (Panaxatriol) reduced tumor cell invasion through a reconstituted basement membrane in the transwell chamber. Increased GR (glucocorticoid receptor) in the nucleus of HT1080 human fibrosarcoma cells treated by PT. GR-induced down-regulation of MMP-9 by PT contributes to reduce the invasive capacity of HT1080 cells[5]. Aerobic exercise and PT (Panaxatriol) ingestion may contribute to maintain skeletal muscle mass through the amelioration of insulin resistance[6].
搜索
