Panaxatriol

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Chemical Structure| 32791-84-7 同义名 : NSC 308880
CAS号 : 32791-84-7
货号 : A215146
分子式 : C30H52O4
纯度 : 98%
分子量 : 476.731
MDL号 : MFCD00210541
存储条件：

Pure form Sealed in dry,2-8°C

In solvent -20°C:3-6个月-80°C:12个月
溶解度 :

DMSO: 25 mg/mL(52.44 mM)，配合低频超声助溶，注意：DMSO长时间开封后，会吸水并导致溶解能力下降，请避免使用长期开封的DMSO
动物实验配方：
生物活性
描述 Panaxatriol is a natural product. Panaxatriol (200 mg/kg/d, 3 weeks) can relieve myelosuppression induced by radiation injury[3]. Panaxatriol exerts dosedependent cytotoxic effects on prostate DU-15 cancer cells. The IC50 of panaxatriol was 30 μM. Additionally, panaxatriol induced sub-G1 cell cycle arrest and suppressed the DU-15 cell migration ability in a concentration-dependent manner[4]. PT (Panaxatriol) reduced tumor cell invasion through a reconstituted basement membrane in the transwell chamber. Increased GR (glucocorticoid receptor) in the nucleus of HT1080 human fibrosarcoma cells treated by PT. GR-induced down-regulation of MMP-9 by PT contributes to reduce the invasive capacity of HT1080 cells[5]. Aerobic exercise and PT (Panaxatriol) ingestion may contribute to maintain skeletal muscle mass through the amelioration of insulin resistance[6].
实验方案
1mg 5mg 10mg

1 mM

5 mM

10 mM

2.10mL

0.42mL

0.21mL

10.49mL

2.10mL

1.05mL

20.98mL

4.20mL

2.10mL
参考文献

[1]Kim TH, Lee SM. The effects of ginseng total saponin, panaxadiol and panaxatriol on ischemia/reperfusion injury in isolated rat heart. Food Chem Toxicol. 2010 Jun;48(6):1516-20.

[2]Liu FY, Wang JN, et al, Zhang JD. Effect of panaxatriol on hematogenesis and granulocyte-macrophage colony stimulating factor in radiation injured mice. Saudi Med J. 2007 Dec;28(12):1791-5.

[3]Liu FY, Wang JN, Yu SD, Wang B, Zhang JD. Effect of panaxatriol on hematogenesis and granulocyte-macrophage colony stimulating factor in radiation injured mice. Saudi Med J. 2007 Dec;28(12):1791-5

[4]Yu R, Zhang Y, Xu Z, Wang J, Chen B, Jin H. Potential antitumor effects of panaxatriol against DU-15 human prostate cancer cells is mediated via mitochondrial mediated apoptosis, inhibition of cell migration and sub-G1 cell cycle arrest. J BUON. 2018 Jan-Feb;23(1):200-204

[5]Park MT, Cha HJ, Jeong JW, Kim SI, Chung HY, Kim ND, Kim OH, Kim KW. Glucocorticoid receptor-induced down-regulation of MMP-9 by ginseng components, PD and PT contributes to inhibition of the invasive capacity of HT1080 human fibrosarcoma cells. Mol Cells. 1999 Oct 31;9(5):476-83

[6]Takamura Y, Nomura M, Uchiyama A, Fujita S. Effects of Aerobic Exercise Combined with Panaxatriol Derived from Ginseng on Insulin Resistance and Skeletal Muscle Mass in Type 2 Diabetic Mice. J Nutr Sci Vitaminol (Tokyo). 2017;63(5):339-348