PXS-5153A is a selective inhibitor of LOXL2 and LOXL3 with IC50 of <40 nM and 63 nM, respectively.
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描述 | PXS-5153A is a potent, selective, orally active and fast-acting dual inhibitor of LOXL2/LOXL3. In all mammalian species tested, the IC50 value of PXS-5153A for LOXL2 was less than 40 nM. PXS-5153A also inhibited human LOXL3 with an IC50 value of 63 nM. PXS-5153A is 40-fold more selective for LOXL2 than LOX and LOXL1, and >700-fold more selective for other related amine oxidases. PXS-5153A is a fast-acting inhibitor, blocking enzyme activity almost completely within 15 minutes[1]. |
计算器 | ||||
存储液制备 | 1mg | 5mg | 10mg | |
1 mM 5 mM 10 mM |
2.10mL 0.42mL 0.21mL |
10.52mL 2.10mL 1.05mL |
21.03mL 4.21mL 2.10mL |
CAS号 | 2125956-82-1 |
分子式 | C20H25Cl2FN4O2S |
分子量 | 475.408 |
别名 | |
运输 | 蓝冰 |
存储条件 |
粉末 Inert atmosphere,2-8°C 液体 -20°C:3-6个月-80°C:12个月 |
溶解度 | |
动物实验配方 |