N-(1-(苯基乙酰基)-L-脯氨酰)甘氨酸乙酯 /Omberacetam
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货号：A100439
同义名：
Noopept;GVS-111
Noopept is a potent nootropic that improves cognitive ability.
Omberacetam 化学结构
Omberacetam 3D分子结构
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Omberacetam 质控信息
Omberacetam 生物活性
描述
Noopept is a dipeptide analog of the standard cognition enhancer, piracetam. Noopept protects PC12 cell against deleterious actions of Aβ through inhibiting the oxidative damage and calcium overload as well as suppressing the mitochondrial apoptotic pathway. Moreover, neuroprotective properties of noopept likely include its ability to decrease tau phosphorylation and to restore the altered morphology of PC12 cells[3] [4] [5]
Omberacetam 参考文献
[1] Pelsman A, Hoyo-Vadillo C, et al. GVS-111 prevents oxidative damage and apoptosis in normal and Down's syndrome human cortical neurons. Int J Dev Neurosci. 2003 May;21(3):117-24.
[2] Gudasheva TA, Boyko SS, et al. The major metabolite of dipeptide piracetam analogue GVS-111 in rat brain and its similarity to endogenous neuropeptide cyclo-L-prolylglycine. Eur J Drug Metab Pharmacokinet. 1997 Jul-Sep;22(3):245-52.
[3] Ostrovskaya RU, Vakhitova YV, Kuzmina USh, Salimgareeva MKh, Zainullina LF, Gudasheva TA, Vakhitov VA, Seredenin SB. Neuroprotective effect of novel cognitive enhancer noopept on AD-related cellular model involves the attenuation of apoptosis and tau hyperphosphorylation. J Biomed Sci. 2014 Aug 6;21(1):74. doi: 10.1186/s12929-014-0074-2. PMID: 25096780; PMCID: PMC4422191.
[4] Antipova TA, Nikolaev SV, Ostrovskaya PU, Gudasheva TA, Seredenin SB. Dipeptide Piracetam Analogue Noopept Improves Viability of Hippocampal HT-22 Neurons in the Glutamate Toxicity Model. Bull Exp Biol Med. 2016 May;161(1):58-60. doi: 10.1007/s10517-016-3344-z. Epub 2016 Jun 6. PMID: 27265136.
[5] Kolbaev SN, Aleksandrova OP, Sharonova IN, Skrebitsky VG. Effect of Noopept on Dynamics of Intracellular Calcium in Neurons of Cultured Rat Hippocampal Slices. Bull Exp Biol Med. 2018 Jan;164(3):330-333. doi: 10.1007/s10517-018-3983-3. Epub 2018 Jan 8. PMID: 29313229.
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Omberacetam 实验方案
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1mg
5mg
10mg
1 mM
5 mM
10 mM
3.14mL
0.63mL
0.31mL
15.71mL
3.14mL
1.57mL
31.41mL
6.28mL
3.14mL
Omberacetam 技术信息
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