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Omberacetam

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Chemical Structure| 157115-85-0 同义名 : Noopept;GVS-111;DVD-111;N-Phenylacetyl-L-Prolylglycine ethyl ester;SGS-111
CAS号 : 157115-85-0
货号 : A100439
分子式 : C17H22N2O4
纯度 : 98%
分子量 : 318.368
MDL号 : MFCD00941121
存储条件：

粉末 Sealed in dry,Store in freezer, under -20°C

液体 -20°C:3-6个月-80°C:12个月
溶解度 :

DMSO: 105 mg/mL(329.81 mM)，注意：DMSO长时间开封后，会吸水并导致溶解能力下降，请避免使用长期开封的DMSO
动物实验配方：
生物活性
描述 Noopept is a dipeptide analog of the standard cognition enhancer, piracetam. Noopept protects PC12 cell against deleterious actions of Aβ through inhibiting the oxidative damage and calcium overload as well as suppressing the mitochondrial apoptotic pathway. Moreover, neuroprotective properties of noopept likely include its ability to decrease tau phosphorylation and to restore the altered morphology of PC12 cells[3]. Noopept added to the medium before or after glutamic acid improved neuronal survival in a concentration range of 10-11-10-5 M[4]. Noopept increased the frequency of spontaneous calcium transients in neurons of CA1 radial layer in cultured rat hippocampal slices[5].
实验方案
1mg 5mg 10mg

1 mM

5 mM

10 mM

3.14mL

0.63mL

0.31mL

15.71mL

3.14mL

1.57mL

31.41mL

6.28mL

3.14mL
参考文献

[1]Pelsman A, Hoyo-Vadillo C, et al. GVS-111 prevents oxidative damage and apoptosis in normal and Down's syndrome human cortical neurons. Int J Dev Neurosci. 2003 May;21(3):117-24.

[2]Gudasheva TA, Boyko SS, et al. The major metabolite of dipeptide piracetam analogue GVS-111 in rat brain and its similarity to endogenous neuropeptide cyclo-L-prolylglycine. Eur J Drug Metab Pharmacokinet. 1997 Jul-Sep;22(3):245-52.

[3]Ostrovskaya RU, Vakhitova YV, Kuzmina USh, Salimgareeva MKh, Zainullina LF, Gudasheva TA, Vakhitov VA, Seredenin SB. Neuroprotective effect of novel cognitive enhancer noopept on AD-related cellular model involves the attenuation of apoptosis and tau hyperphosphorylation. J Biomed Sci. 2014 Aug 6;21(1):74. doi: 10.1186/s12929-014-0074-2. PMID: 25096780; PMCID: PMC4422191.

[4]Antipova TA, Nikolaev SV, Ostrovskaya PU, Gudasheva TA, Seredenin SB. Dipeptide Piracetam Analogue Noopept Improves Viability of Hippocampal HT-22 Neurons in the Glutamate Toxicity Model. Bull Exp Biol Med. 2016 May;161(1):58-60. doi: 10.1007/s10517-016-3344-z. Epub 2016 Jun 6. PMID: 27265136.

[5]Kolbaev SN, Aleksandrova OP, Sharonova IN, Skrebitsky VG. Effect of Noopept on Dynamics of Intracellular Calcium in Neurons of Cultured Rat Hippocampal Slices. Bull Exp Biol Med. 2018 Jan;164(3):330-333. doi: 10.1007/s10517-018-3983-3. Epub 2018 Jan 8. PMID: 29313229.