货号:A813598 同义名: Octreotide游离态 / SMS 201-995
Octreotide is an analog of somatostatin that binds to the somatostatin receptor 2/3/5. It can increase Gi activity and reduce the production of intracellular cAMP.
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描述 | Octreotide is a somatostatin analog that binds to the somatostatin receptor, mainly subtypes 2, 3, and 5, increases Gi activity, and reduces intracellular cAMP production. Octreotide improved hepatic glycogenesis and decreased FPG (fasting plasma glucose) concentration in rats with HFD (high fat diet)‑induced obesity[3]. Octreotide was shown to reduce the perception of rectal distension without affecting motor pathways or local rectal reflexes[4]. Octreotide improves secretory diarrhoea resulting from neuroendocrine tumours, intestinal infections in AIDS patients, and intestinal graft v host disease[5]. Octreotide was used safely as an adjunctive therapy for the treatment of chylothorax and chylous ascites in neonates[6]. In comparison to the saline-treated group, allodynia was partially attenuated by octreotide, though this was almost completely reversed by morphine. Octreotide has an antinociceptive effect, which was less than morphine[7]. |
NCT号 | 适应症或疾病 | 临床期 | 招募状态 | 预计完成时间 | 地点 |
NCT00742339 | Cirrhosis Hep... 展开 >>atorenal Syndrome 收起 << | Phase 2 Phase 3 | Terminated(Decision of indepen... 展开 >>dent monitoring committee Risk of non-response to treatment significantly higher in midodrine group than in terlipressin group.) 收起 << | - | Italy ... 展开 >> Dept. of Clinical and Experimental Medicine, University of Padova Padova, Italy, 35100 收起 << |
NCT00376064 | Acromegaly | Phase 4 | Completed | - | Germany ... 展开 >> Novartis Investigative Site Aachen, Germany Novartis Investigative Site Berlin, Germany Novartis Investigative Site Bochum, Germany Novartis Investigative Site Erlangen, Germany Novartis Investigative Site Essen, Germany Novartis Investigative Site Greifswald, Germany Novartis Investigative Site Heidelberg, Germany Novartis Investigative Site Koln, Germany Novartis Investigative Site Leipzig, Germany Novartis Investigative Site Marburg, Germany Novartis Investigative Site Muenchen, Germany Novartis Investigative Site Oldenburg, Germany Novartis Investigative Site Regensburg, Germany Novartis Investigative Site Tubingen, Germany Novartis Investigative Site Ulm, Germany Novartis Investigative Site Wurzburg, Germany 收起 << |
NCT00595140 | Acromegaly | Phase 4 | Completed | - | Germany ... 展开 >> Medizinische Klinik - Innenstadt of the University of Munich Munich, Germany, 80336 收起 << |
计算器 | ||||
存储液制备 | 1mg | 5mg | 10mg | |
1 mM 5 mM 10 mM |
0.98mL 0.20mL 0.10mL |
4.91mL 0.98mL 0.49mL |
9.81mL 1.96mL 0.98mL |
CAS号 | 83150-76-9 |
分子式 | C49H66N10O10S2 |
分子量 | 1019.239 |
别名 | Octreotide游离态 ;SMS 201-995 |
运输 | 蓝冰 |
存储条件 |
液体 -20°C:3-6个月-80°C:12个月 粉末 Keep in dark place,Inert atmosphere,Store in freezer, under -20°C |
溶解度 |
H2O: 100 mg/mL(98.11 mM),配合低频超声助溶 |
动物实验配方 |