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奥曲肽 /Octreotide {[allProObj[0].p_purity_real_show]}

货号：A813598 同义名： Octreotide游离态 / SMS 201-995

Octreotide是一种生长抑素的类似物，可与生长抑素受体（2、3、5 亚型）结合，增强 Gi 活性，降低胞内 cAMP 生成，具有抗肿瘤作用，能诱导细胞凋亡，也用于肢端肥大症的研究。

Octreotide 化学结构 CAS号：83150-76-9
Octreotide 化学结构
CAS号：83150-76-9
Octreotide 3D分子结构
CAS号：83150-76-9
Octreotide 化学结构 CAS号：83150-76-9
Octreotide 3D分子结构 CAS号：83150-76-9
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Octreotide 纯度/质量文件 产品仅供科研

货号：A813598 标准纯度： {[allProObj[0].p_purity_real_show]}
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Octreotide 生物活性

描述 Octreotide is a somatostatin analog that binds to the somatostatin receptor, mainly subtypes 2, 3, and 5, increases Gi activity, and reduces intracellular cAMP production. Octreotide improved hepatic glycogenesis and decreased FPG (fasting plasma glucose) concentration in rats with HFD (high fat diet)‑induced obesity[3]. Octreotide was shown to reduce the perception of rectal distension without affecting motor pathways or local rectal reflexes[4]. Octreotide improves secretory diarrhoea resulting from neuroendocrine tumours, intestinal infections in AIDS patients, and intestinal graft v host disease[5]. Octreotide was used safely as an adjunctive therapy for the treatment of chylothorax and chylous ascites in neonates[6]. In comparison to the saline-treated group, allodynia was partially attenuated by octreotide, though this was almost completely reversed by morphine. Octreotide has an antinociceptive effect, which was less than morphine[7].

Octreotide 临床研究

NCT号 适应症或疾病 临床期 招募状态 预计完成时间 地点
NCT00742339 Cirrhosis Hep... 展开 >>atorenal Syndrome 收起 << Phase 2 Phase 3 Terminated(Decision of indepen... 展开 >>dent monitoring committee Risk of non-response to treatment significantly higher in midodrine group than in terlipressin group.) 收起 << - Italy ... 展开 >> Dept. of Clinical and Experimental Medicine, University of Padova Padova, Italy, 35100 收起 <<
NCT00376064 Acromegaly Phase 4 Completed - Germany ... 展开 >> Novartis Investigative Site Aachen, Germany Novartis Investigative Site Berlin, Germany Novartis Investigative Site Bochum, Germany Novartis Investigative Site Erlangen, Germany Novartis Investigative Site Essen, Germany Novartis Investigative Site Greifswald, Germany Novartis Investigative Site Heidelberg, Germany Novartis Investigative Site Koln, Germany Novartis Investigative Site Leipzig, Germany Novartis Investigative Site Marburg, Germany Novartis Investigative Site Muenchen, Germany Novartis Investigative Site Oldenburg, Germany Novartis Investigative Site Regensburg, Germany Novartis Investigative Site Tubingen, Germany Novartis Investigative Site Ulm, Germany Novartis Investigative Site Wurzburg, Germany 收起 <<
NCT00595140 Acromegaly Phase 4 Completed - Germany ... 展开 >> Medizinische Klinik - Innenstadt of the University of Munich Munich, Germany, 80336 收起 <<

Octreotide 参考文献

[1]Deng C, Deng B, et al. Efficacy of long-acting release octreotide for preventing chemotherapy-induced diarrhoea: protocol for a systematic review. BMJ Open. 2017 Jun 21;7(6):e014916.

[2]Raynor K, Murphy WA, et al. Cloned somatostatin receptors: identification of subtype-selective peptides and demonstration of high affinity binding of linear peptides. Mol Pharmacol. 1993 Jun;43(6):838-44.

[3]Wang XX, Ye T, Li M, Li X, Qiang O, Tang CW, Liu R. Effects of octreotide on hepatic glycogenesis in rats with high fat diet‑induced obesity. Mol Med Rep. 2017 Jul;16(1):109-118

[4]Owyang C. Octreotide in gastrointestinal motility disorders. Gut. 1994;35(3 Suppl):S11-4

[5]Farthing MJ. Octreotide in the treatment of refractory diarrhoea and intestinal fistulae. Gut. 1994;35(3 Suppl):S5-10

[6]Zaki SA, Krishnamurthy MB, Malhotra A. Octreotide Use in Neonates: A Case Series. Drugs R D. 2018 Sep;18(3):191-198

[7]Singh P, Ray SB. Comparison of Antinociceptive Effect of Octreotide With Morphine in a Rat Model of Acute Inflammatory Pain. Ann Neurosci. 2021 Jan;28(1-2):13-20

Octreotide 实验方案

计算器
存储液制备 1mg 5mg 10mg

1 mM

5 mM

10 mM

0.98mL

0.20mL

0.10mL

4.91mL

0.98mL

0.49mL

9.81mL

1.96mL

0.98mL

Octreotide 技术信息

CAS号83150-76-9
分子式C49H66N10O10S2
分子量 1019.239
别名 Octreotide游离态 ;SMS 201-995
运输蓝冰
存储条件

In solvent -20°C:3-6个月-80°C:12个月

Pure form Keep in dark place,Inert atmosphere,Store in freezer, under -20°C
溶解方案

H2O: 100 mg/mL(98.11 mM)，配合低频超声助溶
动物实验配方

Tags: Octreotide | SMS 201-995 | Octreotide游离态 | SSTR | AmBeed-信号通路专用抑制剂 | Octreotide 纯度/质量文件 | Octreotide 生物活性 | Octreotide 临床数据 | Octreotide 参考文献 | Octreotide 实验方案 | Octreotide 技术信息

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