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醋酸奥曲肽 /Octreotide acetate {[allProObj[0].p_purity_real_show]}

货号：A589099 同义名： SMS 201-995 acetate

Octreotide acetate是一种长效的合成八肽，其药理作用模仿自然激素生长抑素。

Octreotide acetate 化学结构 CAS号：79517-01-4
Octreotide acetate 化学结构
CAS号：79517-01-4
Octreotide acetate 3D分子结构
CAS号：79517-01-4
Octreotide acetate 化学结构 CAS号：79517-01-4
Octreotide acetate 3D分子结构 CAS号：79517-01-4
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Octreotide acetate 纯度/质量文件 产品仅供科研

货号：A589099 标准纯度： {[allProObj[0].p_purity_real_show]}
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Octreotide acetate 生物活性

描述 Octreotide acetate, a long-acting synthetic analog of native somatostatin, inhibits growth hormone, glucagon, and insulin more potently. Octreotide-treated groups show a significant reduction in the tumor volume when compared with saline group. Octreotide-PPSG (1.4 mg/kg, i.p.) shows greater antitumor effect than Octreotide-soln (100 μg/kg, i.p.). Octreotide-treatments results in significant inhibitory effect on the expression levels of SSTR2 and SSTR5 in primary HCC-bearing rats compared with the saline group[3]. Octreotide can decrease the rate of postoperative complication after pancreatic resection by diminishing exocrine function of the pancreas. Prophylactic octreotide is not effective to inhibit the exocrine secretion of the remnant pancreas and does not decrease the incidence of pancreatic fistula after pancreaticoduodenectomy[4]. The prophylactic use of LAO (long-acting octreotide acetate) did not prevent the incidence or reduce the severity of diarrhea and had no notable impact on patient-reported bowel function or QoL(quality of life)[5]. Octreotide LAR (octreotide acetate) 20 mg shows significant efficacy in terms of objective response rate (PR + SD), biochemical and symptomatic control in patients with metastatic NETs (neuroendocrine tumors) of the GEP system pretreated and progressing on slow release lanreotide[6].

Octreotide acetate 临床研究

NCT号 适应症或疾病 临床期 招募状态 预计完成时间 地点
NCT00274170 Migraine Headache Phase 1 Phase 2 Unknown - United States, Texas ... 展开 >> CR Darnall Army Medical Center Recruiting Ft. Hood, Texas, United States, 76544 收起 <<
NCT00616551 Acromegaly Phase 3 Completed - Belarus ... 展开 >> Republican Centre for Medical Rehabilitation and Water-therapy Minsk, Belarus Hungary Semmelweis Egyetem Általános Orvostudományi Budapest, Hungary Romania Institute of Endocrinology "C. I. Parhon" Bucharest Bucharest, Romania Serbia Institute of Endocrinology, University Clinical Center Belgrade, Serbia Slovakia Fakultná Nemocnica s Poliklinkou Bratislava Bratislava, Slovakia Ukraine V.P. Komisarenko Institute of Endocrinology and Metabolism, AMS Ukraine Kiev, Ukraine 收起 <<
NCT00003057 Colorectal Cancer ... 展开 >> Diarrhea 收起 << Phase 3 Completed - -

Octreotide acetate 参考文献

[1]Wang M, Shan F, et al. Pharmacokinetic and pharmacodynamic study of a phospholipid-based phase separation gel for once a month administration of octreotide. J Control Release. 2016 May 28;230:45-56.

[2]Kim S, Hosoya K, et al. Treatment of Gastrin-Secreting Tumor With Sustained-Release Octreotide Acetate in a Dog. J Am Anim Hosp Assoc. 2015 Nov-Dec;51(6):407-12.

[3]Wang M, Shan F, Zou Y, Sun X, Zhang ZR, Fu Y, Gong T. Pharmacokinetic and pharmacodynamic study of a phospholipid-based phase separation gel for once a month administration of octreotide. J Control Release. 2016 May 28;230:45-56

[4]You DD, Paik KY, Park IY, Yoo YK. Randomized controlled study of the effect of octreotide on pancreatic exocrine secretion and pancreatic fistula after pancreatoduodenectomy. Asian J Surg. 2019 Feb;42(2):458-463

[5]Zachariah B, Gwede CK, James J, Ajani J, Chin LJ, Donath D, Rosenthal SA, Kane BL, Rotman M, Berk L, Kachnic LA. Octreotide acetate in prevention of chemoradiation-induced diarrhea in anorectal cancer: randomized RTOG trial 0315. J Natl Cancer Inst. 2010 Apr 21;102(8):547-56

[6]Ricci S, Antonuzzo A, Galli L, Ferdeghini M, Bodei L, Orlandini C, Conte PF. Octreotide acetate long-acting release in patients with metastatic neuroendocrine tumors pretreated with lanreotide. Ann Oncol. 2000 Sep;11(9):1127-30

Octreotide acetate 实验方案

计算器
存储液制备 1mg 5mg 10mg

1 mM

5 mM

10 mM

0.93mL

0.19mL

0.09mL

4.63mL

0.93mL

0.46mL

9.27mL

1.85mL

0.93mL

Octreotide acetate 技术信息

CAS号79517-01-4
分子式C51H70N10O12S2
分子量 1079.291
别名 SMS 201-995 acetate
运输蓝冰
存储条件

In solvent -20°C:3-6个月-80°C:12个月

Pure form Inert atmosphere,Store in freezer, under -20°C
溶解方案

DMSO: 250 mg/mL(231.63 mM)，配合低频超声助溶，注意：DMSO长时间开封后，会吸水并导致溶解能力下降，请避免使用长期开封的DMSO

H2O: 25 mg/mL(23.16 mM)，配合低频超声助溶

请根据您的动物给药指南选择适当的溶解方案。
以下溶解方案都请先按照体外实验的方式配制澄清的储备液，再依次添加助溶剂：
——为保证实验结果的可靠性，澄清的储备液可以根据储存条件，适当保存；体内实验的工作液，建议现用现配，当天使用； 以下溶剂前显示的百分比是指该溶剂在终溶液中的体积占比；如在配制过程中出现沉淀、析出现象，可以通过加热和/或超声的方式助溶
方案一
方案二
配制的工作液建议现用现配，短期内尽快用完。 以下溶剂前显示的百分比是指该溶剂在终溶液中的体积占比；如在配制过程中出现沉淀、析出现象，可以通过加热和/或超声的方式助溶。
方案一
动物实验配方

Tags: Octreotide | 79517-01-4 | SMS 201-995 | Somatostatin Receptor Agonist | GPCR/G Protein | Neuronal Signaling | Somatostatin Receptor | 仅供科研使用 | AmBeed-信号通路专用抑制剂 | Octreotide acetate 纯度/质量文件 | Octreotide acetate 生物活性 | Octreotide acetate 临床数据 | Octreotide acetate 参考文献 | Octreotide acetate 实验方案 | Octreotide acetate 技术信息

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