Ambeed 大中华区 CN | ZH

中文 - ZH English - EN

Ambeed.cn

搜索

关键字搜索批量搜索

首页 收藏 购物车0
首页 /
抑制剂/激动剂
抗生素和抗病毒
/
抗感染
功能
/
Antifungal
抗真菌抗生素 抗细菌抗生素
/ Nystatin

Nystatin {[allProObj[0].p_purity_real_show]}

货号：A326754 同义名： 制霉菌素 / Fungicidin

Nystatin是一种多烯类抗真菌剂，与真菌细胞膜上的甾醇结合，使细胞膜通透性改变。Nystatin能够抑制真菌的活性，可用于细胞培养，推荐浓度为 0.05mg/mL。

Nystatin 化学结构 CAS号：1400-61-9
Nystatin 化学结构
CAS号：1400-61-9
Nystatin 3D分子结构
CAS号：1400-61-9
Nystatin 化学结构 CAS号：1400-61-9
Nystatin 3D分子结构 CAS号：1400-61-9
规格 价格 会员价 库存 数量
{[ item.pr_size ]}

{[ getRatePrice(item.pr_rmb, 1,1) ]}

{[ getRatePrice(item.pr_rmb_sale, 1,1) ]} {[ suihuo_tips(item.pr_tag_price) ]}

{[ getRatePrice(item.pr_rmb, 1,1) ]}

{[ getRatePrice(item.pr_rmb,item.pr_rate,1) ]} {[ suihuo_tips(item.pr_tag_price) ]} 		{[ getRatePrice(item.pr_rmb, 1,1) ]}{[ suihuo_tips(item.pr_tag_price) ]} {[ getRatePrice(item.pr_rmb_sale, 1,1) ]} {[ getRatePrice(item.pr_rmb,item.pr_rate,item.mem_rate) ]} {[ getRatePrice(item.pr_rmb,1,item.mem_rate) ]} 现货 1周 咨询 - +
购物车0 收藏 询单

Nystatin 纯度/质量文件 产品仅供科研

货号：A326754 标准纯度： {[allProObj[0].p_purity_real_show]}
批次查询： 批次纯度:

全球学术期刊中引用的产品

• Adv. Funct. Mater., 2025, 2500696. Ambeed. [ A245395 ]
• JACS, 2025. Ambeed. [ A505336 ]
• Sci. Adv., 2025, 11(13): eadr0006. Ambeed. [ A152627 ]
• ACS Appl. Mater. Interfaces, 2025, 17(12): 18046-18058. Ambeed. [ A739356 , A171817 ]
• Food Res. Int., 2025, 116191. Ambeed. [ A1452012 ]
更多 >

Nystatin 生物活性

描述 Nystatin is an orally active polyene antifungal antibiotic effective against yeast and mycoplasma. Nystatin results in a significant reduction in buccal epithelial cell adhesion of all six Candida species[3]. Histopathological results showed that liposomal nystatin cleared the lungs, spleen, pancreas, kidney, and liver of Aspergillus and that there was no organ damage at the day 5 time point, which was after only three doses of liposomal nystatin. Based on these results in mice, it is probable that liposomal nystatin will be effective against Aspergillus infection in humans[4]. Nystatin-enhanced internalization of endostatin also increases its inhibitory effects on endothelial cell tube formation and migration. More importantly, combined treatment with nystatin and endostatin selectively enhances endostatin uptake and biodistribution in tumor blood vessels and tumor tissues but not in normal tissues of tumor-bearing mice, ultimately resulting in elevated antiangiogenic and antitumor efficacies of endostatin in vivo[5].
体外研究 Nystatin causes a significant reduction in buccal epithelial cell adhesion in all six Candida species[6]. Nystatin is an antibiotic that increases the permeability of the plasma membrane to small monovalent ions, including chloride ions.Nystatin increases apical chloride permeability, such that trans-epithelial transport of chloride ions is limited by translocation across the basolateral membranes of tracheal epithelial cells, largely reflecting the activity of co-transporter proteins.Nystatin (400 units/mL) increases the basal level of trans-epithelial 36Cl flux by approximately 1.5-fold and eliminated the stimulation of this flux by UTP.Nystatin treatment also eliminated the stimulation of binding of saturable basolateral [3H]bumetanide by UTP, a measure of the function of Na-K-Cl co-transporter proteins in these cells; stimulation of binding by isoproterenol was only mildly inhibited by Nystatin treatment[7]. Nystatin significantly enhances endothelial uptake by endothelial cells by converting endothelial inhibitor internalisation primarily to a lattice protein-mediated pathway.Nystatin-enhanced endothelial inhibitor internalisation also increases its inhibitory effect on endothelial cell tube formation and migration[8].

Nystatin 临床研究

NCT号 适应症或疾病 临床期 招募状态 预计完成时间 地点
NCT00659971 Oral Candidiasis Phase 2 Completed - United States, North Carolina ... 展开 >> Rosedale Infectious Disease Huntersville, North Carolina, United States, 28078 收起 <<
NCT01111942 Head and Neck Cancer Early Phase 1 Terminated(lack of enrollment) - United States, Illinois ... 展开 >> Southern Illinois University School of Medicine Springfield, Illinois, United States, 62701 收起 <<
NCT00814359 Head and Neck Cancer ... 展开 >> Mucositis 收起 << Phase 3 Completed - Canada, Ontario ... 展开 >> Juravinski Cancer Centre Hamilton, Ontario, Canada, L8V 5C2 收起 <<

Nystatin 参考文献

[1]Chen Y, Wang S, et al. Cholesterol sequestration by nystatin enhances the uptake and activity of endostatin in endothelium via regulating distinct endocytic pathways. Blood. 2011 Jun 9;117(23):6392-403.

[2]Brautaset T, Borgos SE, et al. Site-specific mutagenesis and domain substitutions in the loading module of the nystatin polyketide synthase, and their effects on nystatin biosynthesis in Streptomyces noursei. J Biol Chem. 2003 Apr 25;278(17):14913-9.

[3]Ellepola AN, Panagoda GJ, Samaranayake LP. Adhesion of oral Candida species to human buccal epithelial cells following brief exposure to nystatin. Oral Microbiol Immunol. 1999 Dec;14(6):358-63

[4]Wallace TL, Paetznick V, Cossum PA, Lopez-Berestein G, Rex JH, Anaissie E. Activity of liposomal nystatin against disseminated Aspergillus fumigatus infection in neutropenic mice. Antimicrob Agents Chemother. 1997 Oct;41(10):2238-43

[5]Chen Y, Wang S, Lu X, Zhang H, Fu Y, Luo Y. Cholesterol sequestration by nystatin enhances the uptake and activity of endostatin in endothelium via regulating distinct endocytic pathways. Blood. 2011 Jun 9;117(23):6392-403

[6]Ellepola AN, et al. Adhesion of oral Candida species to human buccal epithelial cells following brief exposure to nystatin. Oral Microbiol Immunol. 1999 Dec;14(6):358-63.

[7]Haas M, et al. Na-K-Cl cotransport in nystatin-treated tracheal cells: regulation by isoproterenol, apical UTP, and [Cl]i. Am J Physiol. 1994 May;266(5 Pt 1):C1440-52.

[8]Chen Y, et al. Cholesterol sequestration by nystatin enhances the uptake and activity of endostatin in endothelium via regulating distinct endocytic pathways. Blood. 2011 Jun 9;117(23):6392-403.

Nystatin 实验方案

计算器
存储液制备 1mg 5mg 10mg

1 mM

5 mM

10 mM

1.08mL

0.22mL

0.11mL

5.40mL

1.08mL

0.54mL

10.80mL

2.16mL

1.08mL

Nystatin 技术信息

CAS号1400-61-9
分子式C47H75NO17
分子量 926.09
SMILES Code C[C@@H]1OC(C[C@H](O)C[C@H](O)C[C@H](O)CC[C@@H](O)[C@H](O)C[C@@](O)(O[C@H]2C[C@H](/C=C/C=C/C=C/C=C/CC/C=C/C=C/[C@@H]([C@@H](O)[C@H]1C)C)O[C@H]3[C@@H](O)[C@@H](N)[C@H](O)[C@@H](C)O3)C[C@H](O)[C@H]2C(O)=O)=O
MDL No. MFCD00036240
别名 制霉菌素 ;Fungicidin
运输蓝冰
存储条件

In solvent -20°C:3-6个月-80°C:12个月

Pure form Keep in dark place, inert atmosphere, store in freezer, under -20°C
溶解方案

DMSO: 50 mg/mL(53.99 mM)，配合低频超声助溶，注意：DMSO长时间开封后，会吸水并导致溶解能力下降，请避免使用长期开封的DMSO

Tags: Nystatin | Fungicidin | 制霉菌素 | Antifungal | AmBeed-信号通路专用抑制剂 | Nystatin 纯度/质量文件 | Nystatin 生物活性 | Nystatin 临床数据 | Nystatin 参考文献 | Nystatin 实验方案 | Nystatin 技术信息

Ambeed 相关网站 Ambeed.cn Ambeed.com
Ambeed
关于我们
联系我们
资讯中心
网站地图
产品手册
  • 批次文件查询
    • 客户支持
    技术支持
    专业术语
    缩略词释义
    质量手册
    产品咨询
    计算器
    活动政策
    订购方法
    积分商城
    活动声明
    联系我们
    400-920-2911 sales@ambeed.cn tech@ambeed.cn
    Ambeed 只为有资质的科研机构、医药企业基于科学研究或药证申报的用途提供医药研发服务，不为任何个人或者非科研性质用途提供服务。

    尊敬的 Ambeed 客户您好，
    请您选择所在区域，我们将转接对应客服为您服务！

    热门区域

    A

    B

    C

    F

    G

    H

    J

    L

    N

    Q

    S

    T

    X

    Y

    Z

    热 A B C F G H J L N Q S T X Y Z