Nystatin

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Chemical Structure| 1400-61-9 同义名 : 制霉菌素 ;Fungicidin
CAS号 : 1400-61-9
货号 : A326754
分子式 : C47H75NO17
纯度 : 4840 iu/mg
分子量 : 926.09
MDL号 : MFCD00036240
存储条件：

Pure form Keep in dark place, inert atmosphere, store in freezer, under -20°C

In solvent -20°C:3-6个月-80°C:12个月
溶解度 :

DMSO: 50 mg/mL(53.99 mM)，配合低频超声助溶，注意：DMSO长时间开封后，会吸水并导致溶解能力下降，请避免使用长期开封的DMSO
动物实验配方：
生物活性
描述 Nystatin is an orally active polyene antifungal antibiotic effective against yeast and mycoplasma. Nystatin results in a significant reduction in buccal epithelial cell adhesion of all six Candida species[3]. Histopathological results showed that liposomal nystatin cleared the lungs, spleen, pancreas, kidney, and liver of Aspergillus and that there was no organ damage at the day 5 time point, which was after only three doses of liposomal nystatin. Based on these results in mice, it is probable that liposomal nystatin will be effective against Aspergillus infection in humans[4]. Nystatin-enhanced internalization of endostatin also increases its inhibitory effects on endothelial cell tube formation and migration. More importantly, combined treatment with nystatin and endostatin selectively enhances endostatin uptake and biodistribution in tumor blood vessels and tumor tissues but not in normal tissues of tumor-bearing mice, ultimately resulting in elevated antiangiogenic and antitumor efficacies of endostatin in vivo[5].
临床研究
NCT号 适应症或疾病 临床期 招募状态 预计完成时间 地点
NCT00659971 Oral Candidiasis Phase 2 Completed - United States, North Carolina ... 展开 >> Rosedale Infectious Disease Huntersville, North Carolina, United States, 28078 收起 <<
NCT01111942 Head and Neck Cancer Early Phase 1 Terminated(lack of enrollment) - United States, Illinois ... 展开 >> Southern Illinois University School of Medicine Springfield, Illinois, United States, 62701 收起 <<
NCT00814359 Head and Neck Cancer ... 展开 >> Mucositis 收起 << Phase 3 Completed - Canada, Ontario ... 展开 >> Juravinski Cancer Centre Hamilton, Ontario, Canada, L8V 5C2 收起 <<
实验方案
1mg 5mg 10mg

1 mM

5 mM

10 mM

1.08mL

0.22mL

0.11mL

5.40mL

1.08mL

0.54mL

10.80mL

2.16mL

1.08mL
参考文献

[1]Chen Y, Wang S, et al. Cholesterol sequestration by nystatin enhances the uptake and activity of endostatin in endothelium via regulating distinct endocytic pathways. Blood. 2011 Jun 9;117(23):6392-403.

[2]Brautaset T, Borgos SE, et al. Site-specific mutagenesis and domain substitutions in the loading module of the nystatin polyketide synthase, and their effects on nystatin biosynthesis in Streptomyces noursei. J Biol Chem. 2003 Apr 25;278(17):14913-9.

[3]Ellepola AN, Panagoda GJ, Samaranayake LP. Adhesion of oral Candida species to human buccal epithelial cells following brief exposure to nystatin. Oral Microbiol Immunol. 1999 Dec;14(6):358-63

[4]Wallace TL, Paetznick V, Cossum PA, Lopez-Berestein G, Rex JH, Anaissie E. Activity of liposomal nystatin against disseminated Aspergillus fumigatus infection in neutropenic mice. Antimicrob Agents Chemother. 1997 Oct;41(10):2238-43

[5]Chen Y, Wang S, Lu X, Zhang H, Fu Y, Luo Y. Cholesterol sequestration by nystatin enhances the uptake and activity of endostatin in endothelium via regulating distinct endocytic pathways. Blood. 2011 Jun 9;117(23):6392-403

[6]Ellepola AN, et al. Adhesion of oral Candida species to human buccal epithelial cells following brief exposure to nystatin. Oral Microbiol Immunol. 1999 Dec;14(6):358-63.

[7]Haas M, et al. Na-K-Cl cotransport in nystatin-treated tracheal cells: regulation by isoproterenol, apical UTP, and [Cl]i. Am J Physiol. 1994 May;266(5 Pt 1):C1440-52.

[8]Chen Y, et al. Cholesterol sequestration by nystatin enhances the uptake and activity of endostatin in endothelium via regulating distinct endocytic pathways. Blood. 2011 Jun 9;117(23):6392-403.