Nitrofurazone is a nitrofuran-class antimicrobial organic compound used as a topical antibiotic ointment effective against gram-positive bacteria, gram-negative bacteria, and on the treatment of trypanosomiasis.
Nitrofurazone, a nitroaromatic drug, is a broad spectrum antibiotic which has until now been considered as activated in bacteria by nitroreductases. Nitrofurazone-coated urinary catheter segments inhibited 51 (75%) of 70 urinary bacterial isolates from patients with indwelling catheters. All strains except the Pseudomonas spp. were inhibited by < or = 64 mg of nitrofurazone per mL[3]. On administration to rats at a subtoxic dose, the antibiotic nitrofurazone (NF) has been shown to increase hepatocyte DNA synthesis and liver weight in a dose-dependent manner, with no histological or biochemical evidence of cell damage or necrosis[4].
United States, Kentucky
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University of Louisville
Recruiting
Louisville, Kentucky, United States, 40202
Contact: Julio A Ramirez, MD 502-852-1148 jarami01@louisville.edu
Contact: David Seligson, MD 502-852-0923 d0seli01@louisville.edu
Sub-Investigator: Forest Arnold, DO
Sub-Investigator: Timothy Wiemkwn, PhD
Sub-Investigator: Robert Kelley, PhD
Sub-Investigator: James Summersgill, PhD
Sub-Investigator: Ruth Carrico, PhD
Sub-Investigator: Julie Harting, PharmD
Sub-Investigator: Paula Peyrani, MD
Principal Investigator: David Seligson, MD
Sub-Investigator: Craig Roberts, MD
Principal Investigator: Julio Ramirez, MD 收起 <<
United States, Oklahoma
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OU Medical Center Laboratory
Recruiting
Oklahoma City, Oklahoma, United States, 73104
Contact: William C Dooley, M.D., F.A.C.S. 405-206-5670 William-Dooley@ouhsc.edu
Contact: Linda White, R.N. (949) 300-9576 lwhite@whmed.com
United States, Texas
MD Anderson Cancer Center
Recruiting
Houston, Texas, United States, 77030
Contact: Henry Kuerer, M.D. 713-745-5043 lboehnke@mdanderson.org
Contact: Linda White, R.N. 949 300-9576 lwhite@whmed.com 收起 <<
United States, Kentucky
... 展开 >>
University of Louisville
Recruiting
Louisville, Kentucky, United States, 40202
Contact: Julio A Ramirez, MD 502-852-1148 jarami01@louisville.edu
Contact: David Seligson, MD 502-852-0923 d0seli01@louisville.edu
Sub-Investigator: Forest Arnold, DO
Sub-Investigator: Timothy Wiemkwn, PhD
Sub-Investigator: Robert Kelley, PhD
Sub-Investigator: James Summersgill, PhD
Sub-Investigator: Ruth Carrico, PhD
Sub-Investigator: Julie Harting, PharmD
Sub-Investigator: Paula Peyrani, MD
Principal Investigator: David Seligson, MD
Sub-Investigator: Craig Roberts, MD
Principal Investigator: Julio Ramirez, MD 收起 <<
United States, Oklahoma
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OU Medical Center Laboratory
Recruiting
Oklahoma City, Oklahoma, United States, 73104
Contact: William C Dooley, M.D., F.A.C.S. 405-206-5670 William-Dooley@ouhsc.edu
Contact: Linda White, R.N. (949) 300-9576 lwhite@whmed.com
United States, Texas
MD Anderson Cancer Center
Recruiting
Houston, Texas, United States, 77030
Contact: Henry Kuerer, M.D. 713-745-5043 lboehnke@mdanderson.org
Contact: Linda White, R.N. 949 300-9576 lwhite@whmed.com 收起 <<
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