产品说明书
Nitrofurazone
 |
同义名 : | Nitrofural;Furacilin;Dermofural;NSC 44009;NSC 2100;NSC 1602 |
| CAS号 : | 59-87-0 | |
| 货号 : | A129741 | |
| 分子式 : | C6H6N4O4 | |
| 纯度 : | 98+% | |
| 分子量 : | 198.14 | |
| MDL号 : | MFCD00003225 | |
| 存储条件： |
粉末 Keep in dark place,Sealed in dry,2-8°C 液体 -20°C:3-6个月-80°C:12个月 |
|
| 溶解度 : |
DMSO: 150 mg/mL(757.04 mM)，注意：DMSO长时间开封后，会吸水并导致溶解能力下降，请避免使用长期开封的DMSO |
|
| 动物实验配方： |
IP 2% DMSO+2% Tween80+30% PEG300+water 2 mg/mL clear PO 0.5% CMC-Na 65 mg/mL suspension |
| 生物活性 | |||
|---|---|---|---|
| 描述 | Nitrofurazone, a nitroaromatic drug, is a broad spectrum antibiotic which has until now been considered as activated in bacteria by nitroreductases. Nitrofurazone-coated urinary catheter segments inhibited 51 (75%) of 70 urinary bacterial isolates from patients with indwelling catheters. All strains except the Pseudomonas spp. were inhibited by < or = 64 mg of nitrofurazone per mL[3]. On administration to rats at a subtoxic dose, the antibiotic nitrofurazone (NF) has been shown to increase hepatocyte DNA synthesis and liver weight in a dose-dependent manner, with no histological or biochemical evidence of cell damage or necrosis[4]. | ||
| 临床研究 | |||||
|---|---|---|---|---|---|
| NCT号 | 适应症或疾病 | 临床期 | 招募状态 | 预计完成时间 | 地点 |
| NCT02099240 | Osteomyelitis | Early Phase 1 | Recruiting | September 2019 | United States, Kentucky ... 展开 >> University of Louisville Recruiting Louisville, Kentucky, United States, 40202 Contact: Julio A Ramirez, MD 502-852-1148 jarami01@louisville.edu Contact: David Seligson, MD 502-852-0923 d0seli01@louisville.edu Sub-Investigator: Forest Arnold, DO Sub-Investigator: Timothy Wiemkwn, PhD Sub-Investigator: Robert Kelley, PhD Sub-Investigator: James Summersgill, PhD Sub-Investigator: Ruth Carrico, PhD Sub-Investigator: Julie Harting, PharmD Sub-Investigator: Paula Peyrani, MD Principal Investigator: David Seligson, MD Sub-Investigator: Craig Roberts, MD Principal Investigator: Julio Ramirez, MD 收起 << |
| NCT00669747 | Ductal Carcinoma In Situ | Phase 2 | Unknown | December 2009 | United States, Oklahoma ... 展开 >> OU Medical Center Laboratory Recruiting Oklahoma City, Oklahoma, United States, 73104 Contact: William C Dooley, M.D., F.A.C.S. 405-206-5670 William-Dooley@ouhsc.edu Contact: Linda White, R.N. (949) 300-9576 lwhite@whmed.com United States, Texas MD Anderson Cancer Center Recruiting Houston, Texas, United States, 77030 Contact: Henry Kuerer, M.D. 713-745-5043 lboehnke@mdanderson.org Contact: Linda White, R.N. 949 300-9576 lwhite@whmed.com 收起 << |
| NCT00192985 | Trauma Urinar... 展开 >>y Tract Infections 收起 << | Phase 3 | Unknown | - | Denmark ... 展开 >> Rigshospitalet, Copenhagen University Hospital Copenhagen, Denmark, DK-2100 收起 << |
| 实验方案 | |||
|---|---|---|---|
| 1mg | 5mg | 10mg | |
|
1 mM 5 mM 10 mM |
5.05mL 1.01mL 0.50mL |
25.23mL 5.05mL 2.52mL |
50.47mL 10.09mL 5.05mL |
| 参考文献 |
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