β-NADP is an electron acceptor which acts as a key cofactor for electron transfer in the metabolism. Its oxidized form and reduced form are NADP+ and NADPH.
NADP is nicotinamide adenine dinucleotide phosphate, acting as a key cofactor for electron transfer in the metabolism of all organisms, being alternately oxidized (NADP+) and reduced (NADPH)[1]. The nicotinamide adenine dinucleotide (NAD+))/reduced NAD+) (NADH) and NADP+)/reduced NADP+) (NADPH) redox couples are essential for maintaining cellular redox homeostasis and for modulating numerous biological events, including cellular metabolism. Deficiency or imbalance of these two redox couples has been associated with many pathological disorders[2]. Cells maintain NADPH mostly in the reduced form to drive reductive biosynthesis and reactive oxygen species (ROS) detoxification, while the NADH pool is maintained mostly in the oxidized state to catalyze energy-producing reactions[3]. In HeLa cells, mitochondrial pyridine nucleotide pools are connected asymmetrically, where oxidation of mitochondrial NADPH causes oxidation of mitochondrial NADH but not vice versa. The mechanism of this asymmetry is currently unknown but could be the result of the activity of transhydrogenase in the mitochondria. Such asymmetry may be beneficial to the cell since mitochondrial NAD+/NADH ratios fluctuate depending on ATP demand and respiratory fuel availability, while NADP+/NADPH reduction potential may need to remain stable to ensure adequate biosynthetic capacity and guard against oxidative stress[3].
United States, Georgia
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Atlanta VA Medical Center
Recruiting
Decatur, Georgia, United States, 30033
Contact: David Guidot, MD 404-321-6111 ext 6935
Principal Investigator: David Guidot, MD
Sub-Investigator: Ashish Mehta, MD, MSc 收起 <<
United States, Florida
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H. Lee Moffitt Cancer Center and Research Institute
Not yet recruiting
Tampa, Florida, United States, 33612
Contact: Kayoko Kennedy 813-745-1947 kayoko.kennedy@moffitt.org
Contact: Nagi Kumar, Ph.D. 813-745-6885 nagi.kumar@moffitt.org
James A. Haley Veteran's Administration Hospital
Not yet recruiting
Tampa, Florida, United States, 33612
Contact: Cesar Ercole, M.D. 813-910-4088 cesar.ercole1@va.gov
Principal Investigator: Cesar Ercole, M.D. 收起 <<
Italy
... 展开 >> Sapienza Università di Roma
Recruiting
Rome, Italy, 00161
Contact: Francesco Violi, Full Prof +39-06-4461933 francesco.violi@uniroma1.it
Contact: Stefania Basili, Ass Prof +39-06-49974678 stefania.basili@uniroma1.it
Principal Investigator: Francesco Violi, full Prof 收起 <<
United States, Hawaii
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Queens Medical Center
Honolulu, Hawaii, United States, 96813
Singapore
Johns Hopkins Singapore International Medical Center
Singapore, Singapore
Taiwan
Chang Gung Memorial Hospital
Chiayi, Taiwan
Chung-Ho Memorial Hospital, Kaohsiung Medical University
Kaohsiung, Taiwan
National Health Research Institute, Ward Veterans General Hospital
Taipei, Taiwan
Taipei Veterans General Hospital
Taipei, Taiwan
Tri-Service General Hospital
Taipei, Taiwan 收起 <<
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