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货号:A225120 同义名: Narcissoside;Isorhamnetin-3-O-β-D-rutinoside

Narcissoside exhibits protection against mitochondrial induced oxidative stress. It is a flavonol glycoside isolated and purified from the bulbus of Narcissus tazettaL. var. chinensis Roem.

Narcissin 化学结构 CAS号:604-80-8
Narcissin 化学结构
CAS号:604-80-8
Narcissin 3D分子结构
CAS号:604-80-8
Narcissin 化学结构 CAS号:604-80-8
Narcissin 3D分子结构 CAS号:604-80-8
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Narcissin 纯度/质量文件 产品仅供科研

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Narcissin 生物活性

描述 Narcissoside (narcissin) exhibits protection against mitochondrial induced oxidative stress. It is a flavonol glycoside isolated and purified from the bulbus of Narcissus tazettaL. var. chinensis Roem. In BFF(B. flavum flavonoid), synergism of rutin and narcissin could be responsible for stronger protection against mitochondrial induced oxidative stress[3]. Narcissoside is a potent inhibitor of viral COVID 19 protein 6W63. The narcissoside have high affinity and inhibition potential than standard inhibitor X77 (N-(4-tert-butylphenyl)-N-[(1R)-2-(cyclohexylamino)-2-oxo-1-(pyridin-3-yl)ethyl]-1H-imidazole-4-carboxamide)[4]. Narcissin (Narcissoside), a flavonol glycoside, exhibits evident scavenging activity against both authentic ONOO- and SIN-1-derived ONOO- with IC50s of 3.5 and 9.6 μM, respectively[5].

Narcissin 参考文献

[1]Gevrenova R, Kondeva-Burdina M, et al. Flavonoid profiles of three Bupleurum species and in vitro hepatoprotective of activity Bupleurum flavum Forsk. Pharmacogn Mag. 2015 Jan-Mar;11(41):14-23.

[2]Su BN, Pawlus AD, et al. Chemical constituents of the fruits of Morinda citrifolia (Noni) and their antioxidant activity. J Nat Prod. 2005 Apr;68(4):592-5.

[3]Gevrenova R, Kondeva-Burdina M, Denkov N, Zheleva-Dimitrova D. Flavonoid profiles of three Bupleurum species and in vitro hepatoprotective of activity Bupleurum flavum Forsk. Pharmacogn Mag. 2015 Jan-Mar;11(41):14-23

[4]Dubey K, Dubey R. Computation screening of narcissoside a glycosyloxyflavone for potential novel coronavirus 2019 (COVID-19) inhibitor. Biomed J. 2020 Aug;43(4):363-367

[5]Su BN, Pawlus AD, Jung HA, Keller WJ, McLaughlin JL, Kinghorn AD. Chemical constituents of the fruits of Morinda citrifolia (Noni) and their antioxidant activity. J Nat Prod. 2005 Apr;68(4):592-5

Narcissin 实验方案

计算器
存储液制备 1mg 5mg 10mg

1 mM

5 mM

10 mM

1.60mL

0.32mL

0.16mL

8.01mL

1.60mL

0.80mL

16.01mL

3.20mL

1.60mL

Narcissin 技术信息

CAS号604-80-8
分子式C28H32O16
分子量 624.544
别名 Narcissoside;Isorhamnetin-3-O-β-D-rutinoside
运输蓝冰
存储条件

液体 -20°C:3-6个月-80°C:12个月

粉末 Inert atmosphere,2-8°C

溶解度

DMSO: 105 mg/mL(168.12 mM),配合低频超声助溶,注意:DMSO长时间开封后,会吸水并导致溶解能力下降,请避免使用长期开封的DMSO

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