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Narcissin

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Chemical Structure| 604-80-8 同义名 : Narcissoside;Isorhamnetin-3-O-β-D-rutinoside
CAS号 : 604-80-8
货号 : A225120
分子式 : C28H32O16
纯度 : 97%
分子量 : 624.544
MDL号 : MFCD00017734
存储条件：

粉末 Inert atmosphere,2-8°C

液体 -20°C:3-6个月-80°C:12个月
溶解度 :

DMSO: 105 mg/mL(168.12 mM)，配合低频超声助溶，注意：DMSO长时间开封后，会吸水并导致溶解能力下降，请避免使用长期开封的DMSO
动物实验配方：
生物活性
描述 Narcissoside (narcissin) exhibits protection against mitochondrial induced oxidative stress. It is a flavonol glycoside isolated and purified from the bulbus of Narcissus tazettaL. var. chinensis Roem. In BFF(B. flavum flavonoid), synergism of rutin and narcissin could be responsible for stronger protection against mitochondrial induced oxidative stress[3]. Narcissoside is a potent inhibitor of viral COVID 19 protein 6W63. The narcissoside have high affinity and inhibition potential than standard inhibitor X77 (N-(4-tert-butylphenyl)-N-[(1R)-2-(cyclohexylamino)-2-oxo-1-(pyridin-3-yl)ethyl]-1H-imidazole-4-carboxamide)[4]. Narcissin (Narcissoside), a flavonol glycoside, exhibits evident scavenging activity against both authentic ONOO- and SIN-1-derived ONOO- with IC50s of 3.5 and 9.6 μM, respectively[5].
实验方案
1mg 5mg 10mg

1 mM

5 mM

10 mM

1.60mL

0.32mL

0.16mL

8.01mL

1.60mL

0.80mL

16.01mL

3.20mL

1.60mL
参考文献

[1]Gevrenova R, Kondeva-Burdina M, et al. Flavonoid profiles of three Bupleurum species and in vitro hepatoprotective of activity Bupleurum flavum Forsk. Pharmacogn Mag. 2015 Jan-Mar;11(41):14-23.

[2]Su BN, Pawlus AD, et al. Chemical constituents of the fruits of Morinda citrifolia (Noni) and their antioxidant activity. J Nat Prod. 2005 Apr;68(4):592-5.

[3]Gevrenova R, Kondeva-Burdina M, Denkov N, Zheleva-Dimitrova D. Flavonoid profiles of three Bupleurum species and in vitro hepatoprotective of activity Bupleurum flavum Forsk. Pharmacogn Mag. 2015 Jan-Mar;11(41):14-23

[4]Dubey K, Dubey R. Computation screening of narcissoside a glycosyloxyflavone for potential novel coronavirus 2019 (COVID-19) inhibitor. Biomed J. 2020 Aug;43(4):363-367

[5]Su BN, Pawlus AD, Jung HA, Keller WJ, McLaughlin JL, Kinghorn AD. Chemical constituents of the fruits of Morinda citrifolia (Noni) and their antioxidant activity. J Nat Prod. 2005 Apr;68(4):592-5