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描述 | NFAT Transcription Factor Regulator-1 inhibited IL-2 synthesis with an IC50 value of 182 nM. NFAT Transcription Factor Regulator-1 inhibited human and rat PBMC proliferation with IC50 values of 82 nM and 146 nM, respectively. NFAT Transcription Factor Regulator-1 inhibits the production of IL-4 and IL-5 in human T-cell lines, and has a similar effect on IL-2 release[1]. |
Animal study | The inhibitory potency of NFAT Transcription Factor Regulator-1 is approximately 10 times that of cyclosporine, and the inhibitory effects on T cell IL-2 production were comparable to those of NFAT Transcription Factor Regulator-1 and cyclosporine at doses of 3.0 mg/kg and 30 mg/kg, respectively. NFAT Transcription Factor Regulator-1 and cyclosporine at doses of 3.0 mg/kg and 30 mg/kg, respectively, had comparable inhibitory effects on T cell IL-2 production. The effect of blocking T cell cytokine production in monkeys suggests that NFAT Transcription Factor Regulator-1 has similar potential for transplantation as cyclosporine[1]. |
计算器 | ||||
存储液制备 | 1mg | 5mg | 10mg | |
1 mM 5 mM 10 mM |
2.40mL 0.48mL 0.24mL |
12.01mL 2.40mL 1.20mL |
24.02mL 4.80mL 2.40mL |
CAS号 | 245747-71-1 |
分子式 | C17H10F6N4O2 |
分子量 | 416.277 |
别名 | |
运输 | 蓝冰 |
存储条件 |
粉末 Sealed in dry,2-8°C 液体 -20°C:3-6个月-80°C:12个月 |
溶解度 |
DMSO: 105 mg/mL(252.24 mM),配合低频超声助溶,注意:DMSO长时间开封后,会吸水并导致溶解能力下降,请避免使用长期开封的DMSO |
动物实验配方 |