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NFAT Transcription Factor Regulator-1

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Chemical Structure| 245747-71-1 同义名 : -
CAS号 : 245747-71-1
货号 : A1176913
分子式 : C17H10F6N4O2
纯度 : 99%+
分子量 : 416.277
MDL号 : -
存储条件:

粉末 Sealed in dry,2-8°C

液体 -20°C:3-6个月-80°C:12个月

溶解度 :

DMSO: 105 mg/mL(252.24 mM),配合低频超声助溶,注意:DMSO长时间开封后,会吸水并导致溶解能力下降,请避免使用长期开封的DMSO

动物实验配方:
生物活性
描述 NFAT Transcription Factor Regulator-1 inhibited IL-2 synthesis with an IC50 value of 182 nM. NFAT Transcription Factor Regulator-1 inhibited human and rat PBMC proliferation with IC50 values of 82 nM and 146 nM, respectively. NFAT Transcription Factor Regulator-1 inhibits the production of IL-4 and IL-5 in human T-cell lines, and has a similar effect on IL-2 release[1].
实验方案
1mg 5mg 10mg

1 mM

5 mM

10 mM

2.40mL

0.48mL

0.24mL

12.01mL

2.40mL

1.20mL

24.02mL

4.80mL

2.40mL

参考文献

[1]Djuric SW, et al. 3,5-Bis(trifluoromethyl)pyrazoles: a novel class of NFAT transcription factor regulator. J Med Chem. 2000 Aug 10;43(16):2975-81.