ND-646 | ACC Inhibitor | AmBeed-信号通路专用抑制剂

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ND-646 {[allProObj[0].p_purity_real_show]}

货号：A634041

ND-646 is an allosteric inhibitor of the ACC enzymes ACC1 and ACC2 that prevents ACC subunit dimerization-to suppress fatty acid synthesis in vitro and in vivo. Chronic ND-646 treatment of xenograft and genetically engineered mouse models of NSCLC inhibited tumor growth.

ND-646 化学结构
CAS号：1434639-57-2

ND-646 3D分子结构
CAS号：1434639-57-2

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ND-646 纯度/质量文件产品仅供科研

货号：A634041 标准纯度： {[allProObj[0].p_purity_real_show]} 产品说明书

批次查询：批次纯度: COA SDS NMR HPLC CNMR LC-MS

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ND-646 生物活性

描述

ND-646 simultaneously inhibits ACC1 and ACC2, thus preventing ACC2 from compensating for the inhibition of ACC1. ND-646 inhibits the dimerization of the hACC2-BC domain under native conditions. In a cell-free system, ND-646 inhibits the enzymatic activity of hACC1 with an IC50 of 3.5 nM and hACC2 with an IC50 of 4.1 nM^[1].

ND-646 动物研究

Animal study

To assess the effects of prolonged ND-646 treatment on NSCLC tumor progression and to evaluate the impact of bi-daily administration, athymic nude mice with established A549 subcutaneous tumors received oral treatments of either a control vehicle twice daily (BID), ND-646 at 25 mg/kg once daily (QD), ND-646 at 25 mg/kg BID, or ND-646 at 50 mg/kg QD over a span of 31 days. The 25 mg/kg QD dosage of ND-646 proved ineffective in curbing tumor growth. In contrast, ND-646 at 25 mg/kg BID or 50 mg/kg QD markedly reduced the growth of subcutaneous A549 tumors. Throughout the treatment duration, ND-646 was well-tolerated, with no notable weight loss observed, indicating that the maximum tolerated dose (MTD) was not surpassed. Following the final dose, mice were euthanized after 1 hour, and their tissues were processed for either immunohistochemistry (IHC) or immunoblot analysis. Tumors subjected to all ND-646 dosages exhibited a loss of p-ACC detection at 1 hour, confirming effective tumor infiltration and immediate ACC inhibition by ND-646. Importantly, a significant increase in p-EIF2αS51 expression within tumor extracts was only observed at ND-646 dosages that significantly impeded tumor growth (25 mg/kg BID and 50 mg/kg QD)^[1].

ND-646 参考文献

[1]Svensson RU, et al. Inhibition of acetyl-CoA carboxylase suppresses fatty acid synthesis and tumor growth of non-small-cell lung cancer in preclinical models. Nat Med. 2016 Oct;22(10):1108-1119.

ND-646 实验方案

计算器

存储液制备

1mg

5mg

10mg

1 mM

5 mM

10 mM

1.76mL

0.35mL

0.18mL

8.79mL

1.76mL

0.88mL

17.59mL

3.52mL

1.76mL

ND-646 技术信息

CAS号	1434639-57-2
分子式	C₂₈H₃₂N₄O₇S
分子量	568.641

别名
运输	蓝冰

存储条件

粉末 Sealed in dry,2-8°C

液体 -20°C:3-6个月-80°C:12个月

溶解度

DMSO: 105 mg/mL(184.65 mM)，注意：DMSO长时间开封后，会吸水并导致溶解能力下降，请避免使用长期开封的DMSO

动物实验配方

摩尔计算器

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浓度 (mol/L) × 体积 (L) × 分子量 (g/mol)=质量 (g)

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ND-646 纯度/质量文件 产品仅供科研

全球学术期刊中引用的产品

ND-646 质控信息

ND-646 生物活性

ND-646 动物研究

ND-646 参考文献

ND-646 实验方案

ND-646 技术信息

最近浏览的产品

大规格询价

摩尔计算器

靶点

总药量计算器

工作液计算器

细胞研究

临床研究

确认信息

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ND-646 纯度/质量文件产品仅供科研