Nα-Tosyl-L-arginine Methyl Ester HCl | TAME hydrochloride | APC/C Inhibitor

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4,5-羟基萘乙烯 /Nα-Tosyl-L-arginine Methyl Ester HCl {[allProObj[0].p_purity_real_show]}

货号：A169128 同义名： TAME hydrochloride;N-4-Tosyl-L-arginine methyl ester (hydrochloride)

TAME hydrochloride is an inhibitor of anaphase-promoting complex/cyclosome (APC/C or APC), which binds to APC/C and prevents its activation by Cdc20 and Cdh1, produces mitotic arrest[1].

Nα-Tosyl-L-arginine Methyl Ester HCl 化学结构
CAS号：1784-03-8

Nα-Tosyl-L-arginine Methyl Ester HCl 3D分子结构
CAS号：1784-03-8

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Nα-Tosyl-L-arginine Methyl Ester HCl 纯度/质量文件产品仅供科研

货号：A169128 标准纯度： {[allProObj[0].p_purity_real_show]} 产品说明书

批次查询：批次纯度: COA SDS NMR HPLC CNMR LC-MS

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APC 亚型比较

产品名称	APC ↓ ↑	其他靶点	纯度
TAME	✔		{[allProObj[0].p_purity_real_show]}
1. 鼠标悬停在“+”上可以显示相关IC50的具体数值。"+"越多，抑制作用越强。2. "✔"表示该化合物对相应的亚型有抑制作用，但抑制强度暂时没有相关数据。

Nα-Tosyl-L-arginine Methyl Ester HCl 生物活性

描述

The anaphase-promoting complex/cyclosome (APC/C) is a large multi-subunit complex that functions as a RING domain E3 ubiquitin ligase to regulate transitions through the cell cycle, achieved by controlling the defined ubiquitin-dependent degradation of specific cell cycle regulators^[1]. Tos-Arg-OMe HCl (TAME) is a kind of amino acid derivatives, is a substrate for trypsin, plasmin, thrombin, and other proteases. It is also an inhibitor of anaphase-promoting complex/cyclosome (APC/C or APC), which binds to APC/C and prevents its activation by Cdc20 and Cdh1, produces mitotic arrest^[2]. Cell surface Tos-Arg-OMe esterase activity was inhibited by aprotinin, benzamidine, pentamidine, and a tris-amidine derivative (alpha,alpha',alpha''-tris(3-amidinophenoxy)mesitylene)^[3]. Acetone-kaolin activation of plasma produced the expected 30-fold increase in Tos-Arg-OMe esterase activity but no change in immunoreactive tissue kallikrein levels^[4].

Nα-Tosyl-L-arginine Methyl Ester HCl 参考文献

[1]David Barford. Structural interconversions of the anaphase-promoting complex/cyclosome (APC/C) regulate cell cycle transitions. Curr Opin Struct Biol.2020 Apr;61:86-97.

[2]S Liu,et al. Integrin cytoplasmic domain-binding proteins. J Cell Sci. 2000. 113 (Pt 20), 3563-71.

[3]J Chao, H S Margolius. Studies on rat renal cortical cell kallikrein. II. Identification of kallikrein as an ecto-enzyme. Biochim Biophys Acta.1979. 570(2), 330-40.

[4]K Shimamoto, R K Mayfield.et al. Immunoreactive tissue kallikrein in human serum. J Lab Clin Med.1984. 103(5), 731-8.

Nα-Tosyl-L-arginine Methyl Ester HCl 实验方案

计算器

存储液制备

1mg

5mg

10mg

1 mM

5 mM

10 mM

2.64mL

0.53mL

0.26mL

13.20mL

2.64mL

1.32mL

26.39mL

5.28mL

2.64mL

Nα-Tosyl-L-arginine Methyl Ester HCl 技术信息

CAS号	1784-03-8
分子式	C₁₄H₂₃ClN₄O₄S
分子量	378.875

别名	TAME hydrochloride;N-4-Tosyl-L-arginine methyl ester (hydrochloride);Tosylarginine methyl ester;TAME
运输	蓝冰

存储条件

粉末 Inert atmosphere,Room Temperature

液体 -20°C:3-6个月-80°C:12个月

溶解度

DMSO: 150 mg/mL(395.91 mM)，配合低频超声助溶，注意：DMSO长时间开封后，会吸水并导致溶解能力下降，请避免使用长期开封的DMSO

H₂O: 100 mg/mL(263.94 mM)

动物实验配方

4,5-羟基萘乙烯 /Nα-Tosyl-L-arginine Methyl Ester HCl {[allProObj[0].p_purity_real_show]}

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Nα-Tosyl-L-arginine Methyl Ester HCl 生物活性

Nα-Tosyl-L-arginine Methyl Ester HCl 参考文献

Nα-Tosyl-L-arginine Methyl Ester HCl 实验方案

Nα-Tosyl-L-arginine Methyl Ester HCl 技术信息

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4,5-羟基萘乙烯 /Nα-Tosyl-L-arginine Methyl Ester HCl {[allProObj[0].p_purity_real_show]}

Nα-Tosyl-L-arginine Methyl Ester HCl 纯度/质量文件 产品仅供科研

全球学术期刊中引用的产品

Nα-Tosyl-L-arginine Methyl Ester HCl 质控信息

Nα-Tosyl-L-arginine Methyl Ester HCl 生物活性

Nα-Tosyl-L-arginine Methyl Ester HCl 参考文献

Nα-Tosyl-L-arginine Methyl Ester HCl 实验方案

Nα-Tosyl-L-arginine Methyl Ester HCl 技术信息

最近浏览的产品

大规格询价

摩尔计算器

靶点

总药量计算器

工作液计算器

细胞研究

临床研究

确认信息

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