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Molnupiravir {[allProObj[0].p_purity_real_show]}

货号:A1463646

Molnupiravir是一种口服生物可用的高效核糖核苷类类似物,能抑制多种RNA病毒的复制,包括SARS-CoV-2(COVID-19的致病因子)。

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There will be a HazMat fee per item when shipping a dangerous goods. The HazMat fee will be charged to your UPS/DHL/FedEx collect account or added to the invoice unless the package is shipped via Ground service. Ship by air in Excepted Quantity (each bottle), which is up to 1g/1mL for class 6.1 packing group I or II, and up to 25g/25ml for all other HazMat items.

Type HazMat fee for 500 gram (Estimated)
Excepted Quantity USD 0.00
Limited Quantity USD 15-60
Inaccessible (Haz class 6.1), Domestic USD 80+
Inaccessible (Haz class 6.1), International USD 150+
Accessible (Haz class 3, 4, 5 or 8), Domestic USD 100+
Accessible (Haz class 3, 4, 5 or 8), International USD 200+
Molnupiravir 化学结构 CAS号:2492423-29-5
Molnupiravir 化学结构
CAS号:2492423-29-5
Molnupiravir 3D分子结构
CAS号:2492423-29-5
Molnupiravir 化学结构 CAS号:2492423-29-5
Molnupiravir 3D分子结构 CAS号:2492423-29-5
规格 价格 会员价 库存 数量
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Molnupiravir 纯度/质量文件 产品仅供科研

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Molnupiravir 生物活性

描述 Molnupiravir (EIDD-2801) is an antiviral medication that inhibits the replication of certain RNA viruses. Molnupiravir has broad spectrum antiviral activity against influenza virus and multiple coronaviruses, such as SARS-CoV-2, MERS-CoV, SARS-CoV. Molnupiravir (50-500 mg/kg; p.o.; every 12 hours for 3 days) is robustly antiviral and able to prevent SARS-CoV replication and disease[1]. Molnupiravir (7 mg/kg; p.o.; twice daily for 3.5 days) significantly reduces shed virus load and duration of fever[2]. It has recently been tested in COVID-19. 1600mg daily dose of molnupiravir is safe and tolerable, without any serious adverse events up to 5.5 days, and significantly lower time to clearance (RNA negative) with molnupiravir 800mg twice daily. The study also showed a significant reduction in the risk of hospital admission or death by 50% with the treatment of molnupiravir[3].

Molnupiravir 参考文献

[1]Sheahan TP, Sims AC, Zhou S, et al. An orally bioavailable broad-spectrum antiviral inhibits SARS-CoV-2 in human airway epithelial cell cultures and multiple coronaviruses in mice. Sci Transl Med. 2020;12(541):eabb5883.

[2]Toots M, Yoon JJ, Cox RM, et al. Characterization of orally efficacious influenza drug with high resistance barrier in ferrets and human airway epithelia. Sci Transl Med. 2019;11(515):eaax5866.

[3]Singh AK, Singh A, Singh R, Misra A. Molnupiravir in COVID-19: A systematic review of literature. Diabetes Metab Syndr. 2021;15(6):102329.

Molnupiravir 实验方案

计算器
存储液制备 1mg 5mg 10mg

1 mM

5 mM

10 mM

3.04mL

0.61mL

0.30mL

15.18mL

3.04mL

1.52mL

30.37mL

6.07mL

3.04mL

Molnupiravir 技术信息

CAS号2492423-29-5
分子式C13H19N3O7
分子量 329.306
别名
运输蓝冰
存储条件

In solvent -20°C:3-6个月-80°C:12个月

Pure form Sealed in dry,Store in freezer, under -20°C

溶解方案

DMSO: 50 mg/mL(151.83 mM),配合低频超声助溶,注意:DMSO长时间开封后,会吸水并导致溶解能力下降,请避免使用长期开封的DMSO

H2O: 12 mg/mL(36.44 mM),配合低频超声助溶

动物实验配方
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