Mitoquinone mesylate, a TPP-derived antioxidant, is specifically designed to target mitochondria for protection against oxidative stress[1]. Mitoquinone, also known as MitoQ, is a mitochondria-focused antioxidant. Optimal dosages for MitoQ and DecylTPP are determined from dose-response trials during 4-hour cold storage. Mitoquinone's protective effects against cold storage damage are initially assessed using MitoSOX Red, a dye that detects mitochondrial superoxide production. NRK cells under cold storage exhibit approximately a two-fold increase in fluorescence, indicating mitochondrial superoxide generation, compared to untreated cells. Mitoquinone significantly shields against cold storage-induced mitochondrial superoxide production, unlike DecylTPP, which fails to provide protection. Mitoquinone treatment substantially lowers mitochondrial superoxide generation, while kidneys treated with DecylTPP show similar mitochondrial superoxide levels to those subjected to cold storage alone[1].
Mitoquinone mesylate 动物研究
Animal study
Mitoquinone administration markedly mitigates pancreatic edema and neutrophil infiltration. It also causes a dose-dependent rise in serum amylase, nearly doubling at the higher dosage. MitoQ treatment almost doubles lung MPO activity triggered by Caerulein, with a notable increase in serum IL-6 levels at a dosage of 10 mg/kg[2].
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