Mitoquinone mesylate

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Chemical Structure| 845959-50-4 同义名 : MitoQ mesylate;MitoQ10 mesylate;Mitoquinone (mesylate);Mitoubiquinone mesylate
CAS号 : 845959-50-4
货号 : A723561
分子式 : C38H47O7PS
纯度 : 98%
分子量 : 678.814
MDL号 : MFCD30747833
存储条件：

Pure form Inert atmosphere,2-8°C

In solvent -20°C:3-6个月-80°C:6个月
溶解度 :

DMSO: 105 mg/mL(154.68 mM)，配合低频超声，并水浴加热至45℃助溶，注意：DMSO长时间开封后，会吸水并导致溶解能力下降，请避免使用长期开封的DMSO
动物实验配方：
生物活性
描述 Mitoquinone mesylate, a TPP-derived antioxidant, is specifically designed to target mitochondria for protection against oxidative stress[1]. Mitoquinone, also known as MitoQ, is a mitochondria-focused antioxidant. Optimal dosages for MitoQ and DecylTPP are determined from dose-response trials during 4-hour cold storage. Mitoquinone's protective effects against cold storage damage are initially assessed using MitoSOX Red, a dye that detects mitochondrial superoxide production. NRK cells under cold storage exhibit approximately a two-fold increase in fluorescence, indicating mitochondrial superoxide generation, compared to untreated cells. Mitoquinone significantly shields against cold storage-induced mitochondrial superoxide production, unlike DecylTPP, which fails to provide protection. Mitoquinone treatment substantially lowers mitochondrial superoxide generation, while kidneys treated with DecylTPP show similar mitochondrial superoxide levels to those subjected to cold storage alone[1].
实验方案
1mg 5mg 10mg

1 mM

5 mM

10 mM

1.47mL

0.29mL

0.15mL

7.37mL

1.47mL

0.74mL

14.73mL

2.95mL

1.47mL
参考文献

[1]Mitchell T, et al. The mitochondria-targeted antioxidant mitoquinone protects against cold storage injury of renaltubular cells and rat kidneys. J Pharmacol Exp Ther. 2011 Mar;336(3):682-92.

[2]Huang W, et al. Effects of the mitochondria-targeted antioxidant mitoquinone in murine acute pancreatitis. Mediators Inflamm. 2015;2015:901780.