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甲基泼尼松龙琥珀酸钠 /Methylprednisolone succinate sodium {[allProObj[0].p_purity_real_show]}

货号:A276578 同义名: 甲强龙琥珀酸钠 / Methylprednisolone hydrogen succinate sodium;U-9088

Methylprednisolone succinate (Methylprednisolone hydrogen succinate) sodium 是一种具有抗炎作用的糖皮质激素和免疫抑制剂。

Methylprednisolone succinate sodium 化学结构 CAS号:2375-03-3
Methylprednisolone succinate sodium 化学结构
CAS号:2375-03-3
Methylprednisolone succinate sodium 3D分子结构
CAS号:2375-03-3
Methylprednisolone succinate sodium 化学结构 CAS号:2375-03-3
Methylprednisolone succinate sodium 3D分子结构 CAS号:2375-03-3
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Methylprednisolone succinate sodium 纯度/质量文件 产品仅供科研

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Methylprednisolone succinate sodium 生物活性

描述 6α-Methylprednisolone 21-hemisuccinate sodium salt is a glucocorticoid of slightly longer half-life than that of Prednisolone. It has potential uses in anti-inflammatory agents. Methylprednisolone aceponate (MPA) is a non-halogenated corticosteroid with a methyl group at C6, which confers higher intrinsic activity[3]. Methylprednisolone is a synthetic glucocorticoid with a potent and long-acting anti-inflammatory, anti-allergic and immunosuppressant. Methylprednisolone is used in many diseases, such as rheumatic diseases, autoimmune diseases, allergic, anaphylactic shock, asthma. Methylprednisolone was also used in patients with spinal cord injury, in order to minimize neurological damage[4]. There is no difference in efficacy and safety between oral methylprednisolone (oMP) and intravenous methylprednisolone (ivMP). In addition, both routes of administration are equally well tolerated and safe[5].

Methylprednisolone succinate sodium 参考文献

[1]Li X, Zhang XY, et al. Efficacy of methylprednisolone sodium succinate for injection (postotic injection) on the auditory threshold and speech recognition rate of sudden deafness patients. Int J Clin Exp Med. 2015 Aug 15;8(8):14110-4.

[2]Trissel LA, Zhang Y, Xu QA. Physical and chemical stability of palonosetron hydrochloride with dacarbazine and with methylprednisolone sodium succinate during simulated y-site administration. Int J Pharm Compd. 2006 May-Jun;10(3):234-6.

[3]Torrelo A. Methylprednisolone aceponate for atopic dermatitis. Int J Dermatol. 2017 Jun;56(6):691-697

[4]Tęsiorowski M, Potaczek T, Jasiewicz B, Sapa J, Zygmunt M. Metyloprednizolon – ostre urazy rdzeniakręgowego, korzyści czy zagrożenia ? [Methylprednisolone- acute spinal cord injury, benefits or risks?]. Postepy Hig Med Dosw (Online). 2013 Jun 26;67:601-9. Polish

[5]Liu S, Liu X, Chen S, Xiao Y, Zhuang W. Oral versus intravenous methylprednisolone for the treatment of multiple sclerosis relapses: A meta-analysis of randomized controlled trials. PLoS One. 2017 Nov 27;12(11):e0188644

Methylprednisolone succinate sodium 实验方案

计算器
存储液制备 1mg 5mg 10mg

1 mM

5 mM

10 mM

2.01mL

0.40mL

0.20mL

10.07mL

2.01mL

1.01mL

20.14mL

4.03mL

2.01mL

Methylprednisolone succinate sodium 技术信息

CAS号2375-03-3
分子式C26H33NaO8
分子量 496.525
别名 甲强龙琥珀酸钠 ;Methylprednisolone hydrogen succinate sodium;U-9088;6α-Methylprednisolone 21-hemisuccinate Sodium;Methylprednisolone sodium succinate
运输蓝冰
存储条件

In solvent -20°C:3-6个月-80°C:12个月

Pure form Inert atmosphere,Room Temperature

溶解方案

DMSO: 25 mg/mL(50.35 mM),注意:DMSO长时间开封后,会吸水并导致溶解能力下降,请避免使用长期开封的DMSO

H2O: 50 mg/mL(100.7 mM),配合低频超声助溶

请根据您的动物给药指南选择适当的溶解方案。
以下溶解方案都请先按照体外实验的方式配制澄清的储备液,再依次添加助溶剂:
——为保证实验结果的可靠性,澄清的储备液可以根据储存条件,适当保存;体内实验的工作液,建议现用现配,当天使用; 以下溶剂前显示的百分比是指该溶剂在终溶液中的体积占比;如在配制过程中出现沉淀、析出现象,可以通过加热和/或超声的方式助溶
方案一
方案二
动物实验配方
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