Mestranol is an agonist of estrogen receptor. It is used as contraceptives.
HazMat Fee +
There will be a HazMat fee per item when shipping a dangerous goods. The HazMat fee will be charged to your UPS/DHL/FedEx collect account or added to the invoice unless the package is shipped via Ground service. Ship by air in Excepted Quantity (each bottle), which is up to 1g/1mL for class 6.1 packing group I or II, and up to 25g/25ml for all other HazMat items.
Type
HazMat fee for 500 gram (Estimated)
Excepted Quantity
USD 0.00
Limited Quantity
USD 15-60
Inaccessible (Haz class 6.1), Domestic
USD 80+
Inaccessible (Haz class 6.1), International
USD 150+
Accessible (Haz class 3, 4, 5 or 8), Domestic
USD 100+
Accessible (Haz class 3, 4, 5 or 8), International
Mestranol is an inactive prodrug and becomes biologically active on conversion to ethinyl estradiol (EE). Mestranol acts as an estrogen receptor agonist. Mestranol combines with a progestin in vivo and can be used for the research of menopausal hormone or menstrual disorders[3]. When mestranol was tested in mice and rats (studies on dogs and monkeys are still in progress) orally in combination with a progestin, it produced pituitary tumors and vaginal and cervical squamous cell carcinomas. When used alone, mestranol, by the oral route, increased incidences of pituitary tumors in both sexes, mammary tumors in castrated males, and mammary tumors in females of another mouse species[4]. Pharmacokinetally, a 50 micrograms oral dose of mestranol (which itself is inactive) is bioequivalent to a 35 micrograms dose of ethinyl estradiol[5]. Mestranol is a low potency synthetic estrogen that has been shown to be much more stable than 17β-Estradiol(HY-B0141) in hepatoma cell culture. Mestranol (10 μM; 6 days) stimulates the growth of ERpositive MCF-7 WS8 cells up to 250% of control levels, growth stimulation could be partially reversed by tamoxifen[6].
United States, California
... 展开 >>
USC University Hospital
Recruiting
Los Angeles, California, United States, 90033
Principal Investigator: Heather MacDonald, M.D. 收起 <<
United States, Texas
... 展开 >>
Children's Medical Center
Recruiting
Dallas, Texas, United States, 75207
Contact: Ashley Keller, MPH 214-648-2817 ashley.keller@utsouthwestern.edu
Principal Investigator: Raksha Jain, MD, MSCI
UT Southwestern Medical Center
Recruiting
Dallas, Texas, United States, 75390
Contact: Ashley Keller, MPH 214-648-2817 ashley.keller@utsouthwestern.edu
Principal Investigator: Raksha Jain, MD, MSCI
Sub-Investigator: David Finklea, MD 收起 <<
United States, Florida
... 展开 >>
Miami Research Associates
Miami, Florida, United States, 33173-5426
United States, Utah
PRA Health Sciences
Salt Lake City, Utah, United States, 84107 收起 <<
United States, Arkansas
... 展开 >>
Little Rock, Arkansas, United States, 72212
United States, California
Beverly Hills, California, United States, 90211
United States, Florida
Ormond Beach, Florida, United States, 32174
Port Orange, Florida, United States, 32127
United States, Pennsylvania
Duncansville, Pennsylvania, United States, 16635
United States, Texas
San Antonio, Texas, United States, 78222 收起 <<
Ovarian Cancer Risk
... 展开 >> Risk-reducing Surgery
Fallopian Tube Fimbriae
Ovarian Cortical Inclusion Cysts 收起 <<
Early Phase 1
Recruiting
June 2018
United States, California
... 展开 >>
USC Keck School of Medicine
Active, not recruiting
Los Angeles, California, United States, 90089
United States, Michigan
University of Michigan
Recruiting
Ann Arbor, Michigan, United States, 48109
Contact: Ashley Wiensch, MPH 734-615-1703 bomkamp@umich.edu
Contact: Celeste L Pearce, PhD 7347643835 lpearce@umich.edu
Principal Investigator: Celeste L Pearce, PhD
Sub-Investigator: Mark Pearlman, MD
Canada, British Columbia
UBC BC Cancer Agency
Recruiting
Vancouver, British Columbia, Canada, V6T 1Z3
Contact: Khaye Rufin, MPH 604-877-6000 ext 672391 khaye.rufin1@bccancer.bc.ca
Contact: Jessica McAlpine, MD 604-875-5608 jessica.mcalpine@vch.ca
Principal Investigator: Jessica McAlpine, MD
Sub-Investigator: Dianne Miller, MD
Sub-Investigator: Gavin Stuart, MD
Sub-Investigator: Janice Kwon, MD
Sub-Investigator: Mark Carey, MD
Sub-Investigator: Sarah Finlayson, MD
Sub-Investigator: Tom Ehlen, MD
Sub-Investigator: Mark Heywood, MD
Sub-Investigator: Anthony Karnezis, MD, PhD
Sub-Investigator: David Huntsman, MD 收起 <<
搜索
HazMat Fee +
