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/ Mefloquine HCI

盐酸甲氟喹 /Mefloquine HCI {[allProObj[0].p_purity_real_show]}

货号：A192274 同义名： Mefloquin hydrochloride;Mefloquine (hydrochloride)

Mefloquine HCl is a quinolinemethanol derivative with antimalarial properties.

Mefloquine HCI 化学结构 CAS号：51773-92-3
Mefloquine HCI 化学结构
CAS号：51773-92-3
Mefloquine HCI 3D分子结构
CAS号：51773-92-3
Mefloquine HCI 化学结构 CAS号：51773-92-3
Mefloquine HCI 3D分子结构 CAS号：51773-92-3
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Mefloquine HCI 纯度/质量文件 产品仅供科研

货号：A192274 标准纯度： {[allProObj[0].p_purity_real_show]}
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Mefloquine HCI 生物活性

描述 Mefloquine (Hydrochloride) is a quinoline antimalarial drug that is structurally related to the antiarrhythmic agent quinidine. Mefloquine is widely used in both the treatment and prophylaxis of Plasmodium falciparum malaria. Mefloquine can prolong cardiac repolarization, especially when coadministered with halofantrine, an antagonist of the human ether-a-go-go-related gene (HERG) cardiac K+ channel. Using patch-clamp electrophysiology we found that mefloquine inhibited KvLQT1/minK channel currents with an IC50 value of approximately 1 microM[2]. Mefloquine possesses activity against the Mycobacterium tuberculosis (Mtb) as well as against multidrugresistant tuberculosis (MDR) and other types of bacteria[3]. The anti-malarial mefloquine was previously shown to be active against E. multilocularis metacestodes in vitro, and in mice infected by intraperitoneal inoculation of metacestodes when administered at 100 mg/kg by oral gavage twice a week for 12 weeks. After 12 weeks of treatment, the presence of parasite lesions was assessed in a liver squeeze chamber and by PCR, and a significantly reduced parasite load was found in mefloquine-treated animals[4]. Mefloquine (MQ) has a highly selective cytotoxicity that inhibits PCa (prostate cancer) cell growth. MQ also induces hyperpolarization of the mitochondrial membrane potential (MMP), as well as ROS (reactive oxygen species) generation[1].

Mefloquine HCI 临床研究

NCT号 适应症或疾病 临床期 招募状态 预计完成时间 地点
NCT01976325 Malaria Not Applicable Unknown November 2015 Canada, Ontario ... 展开 >> National Capital Region Occupational Health Clinic Recruiting Ottawa, Ontario, Canada, K1A 0K9 Contact: Louise J Levesque, RN, BScN    613-946-5533    louise.j.levesque@hc-sc.gc.ca    Contact: Lisa Taras, MD, CCFP    613-946-6583    lisa.taras@hc-sc.gc.ca    Ottawa Hospital Research Institute Recruiting Ottawa, Ontario, Canada, K1Y 4E9 Contact: Charde A Morgan, MScPH    613-737-8899 ext 72424    cmorgan@ohri.ca    Contact: Anne E McCarthy, MD    613-737-8899 ext 78184    amccarthy@toh.on.ca    Principal Investigator: Anne E McCarthy, MD, MSc          Sub-Investigator: Charde A Morgan, MScPH          International Association for Medical Assistance to Travellers Recruiting Toronto, Ontario, Canada, M6K 3E3 Contact: Tullia Marcolongo    416-652-0137    tullia@iamat.org 收起 <<
NCT00902811 Uncomplicated Falciparum Malar... 展开 >>ia 收起 << Phase 4 Unknown December 2009 Myanmar ... 展开 >> Dabhine and Mingan Clinic Recruiting Sittwe, Rakhine, Myanmar Contact: Pyay Phyo Aung       frank_smithuis@yahoo.com    Principal Investigator: Pyay Phyo Aung, MD          Myit Kyi Nar Clinic Recruiting Kachin, Myanmar Contact: Mya Nee Nyo       frank_smithuis@yahoo.com    Principal Investigator: Mya Nee Nyo, MD          Myothugyi Rural Health Center, Bu Thee Daung Recruiting Maungdaw, Myanmar Contact: Arkar Linn Naing       frank_smithuis@yahoo.com    Principal Investigator: Arkar Linn Naing, MD          Lashio Clinic Recruiting Shan, Myanmar Contact: Naing Nyo, MD          Principal Investigator: Naing Zaw, MD 收起 <<
NCT01107145 Plasmodium Vivax Malaria Phase 4 Terminated(Extremely slow enro... 展开 >>llment) 收起 << - Brazil ... 展开 >> Hospital Geral Maternidade de Cruzeiro do Sul Cruzeiro do Sul, Acre, Brazil Hospital Municipal Teonila Alves Anajas, Para, Brazil Centro de Pesquisa em Patologias Tropicais Porto Velho, Rondonia, Brazil 收起 <<

Mefloquine HCI 参考文献

[1]Yan KH, Yao CJ, Hsiao CH, et al. Mefloquine exerts anticancer activity in prostate cancer cells via ROS-mediated modulation of Akt, ERK, JNK and AMPK signaling. Oncol Lett. 2013;5(5):1541‐1545

[2]Kang J, Chen XL, Wang L, Rampe D. Interactions of the antimalarial drug mefloquine with the human cardiac potassium channels KvLQT1/minK and HERG. J Pharmacol Exp Ther. 2001;299(1):290‐296

[3]da Silva Araújo A, Moraes AM, Lourenço MCS, Pessoa CO, da Silva ET, de Souza MVN. Synthesis and Antibacterial Activity of Mefloquine-Based Analogs Against Sensitive and Resistant Mycobacterium tuberculosis Strains. Curr Top Med Chem. 2019;19(9):683‐689

[4]Rufener R, Ritler D, Zielinski J, et al. Activity of mefloquine and mefloquine derivatives against Echinococcus multilocularis. Int J Parasitol Drugs Drug Resist. 2018;8(2):331‐340

Mefloquine HCI 实验方案

计算器
存储液制备 1mg 5mg 10mg

1 mM

5 mM

10 mM

2.41mL

0.48mL

0.24mL

12.05mL

2.41mL

1.21mL

24.11mL

4.82mL

2.41mL

Mefloquine HCI 技术信息

CAS号51773-92-3
分子式C17H17ClF6N2O
分子量 414.773
别名 Mefloquin hydrochloride;Mefloquine (hydrochloride);Ro 21-5998/001;NSC 157387;Mefloquine HCl
运输蓝冰
存储条件

液体 -20°C:3-6个月-80°C:12个月

粉末 Inert atmosphere,Room Temperature
溶解度

DMSO: 50 mg/mL(120.55 mM)，配合低频超声助溶，注意：DMSO长时间开封后，会吸水并导致溶解能力下降，请避免使用长期开封的DMSO

H2O: 2.5 mg/mL(6.03 mM)，配合低频超声，并水浴加热至45℃助溶
动物实验配方

Tags: Mefloquine HCI | Mefloquin hydrochloride;Mefloquine (hydrochloride);Ro 21-5998/001;NSC 157387;Mefloquine HCl | Insect Repellent | Antiparasitic | AmBeed-信号通路专用抑制剂 | Mefloquine HCI 纯度/质量文件 | Mefloquine HCI 生物活性 | Mefloquine HCI 临床数据 | Mefloquine HCI 参考文献 | Mefloquine HCI 实验方案 | Mefloquine HCI 技术信息

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