There will be a HazMat fee per item when shipping a dangerous goods. The HazMat fee will be charged to your UPS/DHL/FedEx collect account or added to the invoice unless the package is shipped via Ground service. Ship by air in Excepted Quantity (each bottle), which is up to 1g/1mL for class 6.1 packing group I or II, and up to 25g/25ml for all other HazMat items.
Type
HazMat fee for 500 gram (Estimated)
Excepted Quantity
USD 0.00
Limited Quantity
USD 15-60
Inaccessible (Haz class 6.1), Domestic
USD 80+
Inaccessible (Haz class 6.1), International
USD 150+
Accessible (Haz class 3, 4, 5 or 8), Domestic
USD 100+
Accessible (Haz class 3, 4, 5 or 8), International
Progesterone Receptor (PGR) is a member or the steroid receptor superfamily. It mediates the physiological effects of progesterone, which plays a central role in reproductive events associated with the establishment and maintenance of pregnancy. Progesterone Receptor is involved in the regulation of eukaryotic gene expression and affect cellular proliferation and differentiation in target tissues. Depending on the isoform, progesterone receptor functions as transcriptional activator or repressor.
The glucocorticoid receptor (GR) has a dual mode of action: as a transcription factor that binds to glucocorticoid response elements (GRE), both for nuclear and mitochondrial DNA, and as a modulator of other transcription factors. The glucocorticoid receptor affects inflammatory responses, cellular proliferation and differentiation in target tissues. The glucocorticoid receptor is involved in chromatin remodeling, plays a role in rapid mRNA degradation. The glucocorticoid receptor could also act as a coactivator for STAT5-dependent transcription upon growth hormone stimulation.
Medroxyprogesterone acetate is a progestin, a synthetic variant of the human hormone progesterone. Medroxyprogesterone acetate acts as a ligand that binds to progesterone receptor. Reports also suggested that Medroxyprogesterone acetate also binds the glucocorticoid receptor. The details were that Medroxyprogesterone acetate dose dependently increased α-ENaC promoter-driven luciferase activity in M-1 cells, indicating that Medroxyprogesterone acetate regulates α-ENaC in a progesterone receptor-independent manner. Moreover, when tested in HT29 cells, Medroxyprogesterone acetate could only stimulate α-ENaC-driven reporter activity when glucocorticoid receptor was coexpressed[3]. According to another report, thyroid cancer KTC-2 cells incubated with 10-1000 nM Medroxyprogesterone acetate for 2 days showed decreased secretion and mRNA expression of IL-6 and PTHrP in a dose-dependent manner. The finding that KTC-2 cells express glucocorticoid receptor but not progesterone receptor suggested that the effect of Medroxyprogesterone acetate was mediated by glucocorticoid receptor[4].
In a rabbit model of flank wounds, Medroxyprogesterone administrated i.m. at the dose of 35 mg/kg daily prolonged the latent phase of wound healing, slowed the rate and decreased the total amount of contracture[5]. According to a published study evaluating the mnemonic and neurobiological effects of Medroxyprogesterone acetate in surgically menopausal rats, Medroxyprogesterone acetate was given at the low dose of 14 mg or the high dose of 21 mg via implanted Alzet osmotic pumps, which slowly released the agent in vivo. The results were that both doses of Medroxyprogesterone acetate impaired learning. High dose of Medroxyprogesterone acetate impaired delayed memory retention and exacerbated overnight forgetting. Medroxyprogesterone acetate treatment also significantly decreased GAD levels in the hippocampus and significantly increased GAD levels in the entorhinal cort[6].
United States, California
... 展开 >>
San Francisco AIDS Clinic / San Francisco Gen Hosp
San Francisco, California, United States, 941102859
United States, Florida
Univ of Florida Health Science Ctr / Pediatrics
Jacksonville, Florida, United States, 32209
United States, New York
Children's Hosp at Albany Med Ctr
Albany, New York, United States, 12208
SUNY / Erie County Med Ctr at Buffalo
Buffalo, New York, United States, 14215
United States, North Carolina
Univ of North Carolina
Chapel Hill, North Carolina, United States, 275997215
United States, Washington
Univ of Washington
Seattle, Washington, United States, 98104 收起 <<
United States, California
... 展开 >>
San Francisco AIDS Clinic / San Francisco Gen Hosp
San Francisco, California, United States, 941102859
United States, Florida
Univ of Florida Health Science Ctr / Pediatrics
Jacksonville, Florida, United States, 32209
United States, New York
Children's Hosp at Albany Med Ctr
Albany, New York, United States, 12208
SUNY / Erie County Med Ctr at Buffalo
Buffalo, New York, United States, 14215
United States, North Carolina
Univ of North Carolina
Chapel Hill, North Carolina, United States, 275997215
United States, Washington
Univ of Washington
Seattle, Washington, United States, 98104 收起 <<
United States, Colorado
... 展开 >>
University of Colorado Anschutz Medical Campus
Aurora, Colorado, United States, 80045
University of Colorado Boulder Intermountain Neuroimaging Consortium
Boulder, Colorado, United States, 80309 收起 <<
United States, Georgia
... 展开 >>
Grady Health System
Recruiting
Atlanta, Georgia, United States, 30303
The Ponce de Leon Center of the Grady Health System
Recruiting
Atlanta, Georgia, United States, 30308
Emory Clinic
Recruiting
Atlanta, Georgia, United States, 30322
Emory University Clinical Research Network
Recruiting
Atlanta, Georgia, United States, 30322 收起 <<
United States, California
... 展开 >>
Greenbrae, California, United States, 94904
San Diego, California, United States, 92108
United States, Florida
Daytona Beach, Florida, United States, 32114
Miami, Florida, United States, 33136
United States, Michigan
Paw Paw, Michigan, United States, 49079
United States, Nevada
Las Vegas, Nevada, United States, 89122
United States, Pennsylvania
Philadelphia, Pennsylvania, United States, 19114
United States, South Carolina
Columbia, South Carolina, United States, 29201
United States, Virginia
Arlington, Virginia, United States, 22203 收起 <<
United States, Pennsylvania
... 展开 >>
University of Pittsburgh School of Medicine, Center for Family Planning Research
Pittsburgh, Pennsylvania, United States, 15213
United States, Virginia
Easter Virginia Medical School
Norfolk, Virginia, United States, 23507
Dominican Republic
Profamilia
Santo Domingo, Dominican Republic 收起 <<
Egypt
... 展开 >> Women Health Hospital - Assiut university
Recruiting
Assiut, Egypt, 71111
Contact: Mohammed K ALi, MD +201005537951 m_khairy2001@yahoo.com 收起 <<
United States, Georgia
... 展开 >>
Grady Health System
Recruiting
Atlanta, Georgia, United States, 30303
Contact: Lisa Haddad, MD, MS, MPH 404-778-1385 lisa.haddad@emory.edu
Principal Investigator: Lisa Haddad, MD, MS, MPH
The Emory Clinic, Bldg A., 2nd Floor, 1365 Clifton Road, NE
Recruiting
Atlanta, Georgia, United States, 30322
Contact: Lisa Haddad, MD, MS,MPH 404-778-1385 lisa.haddad@emory.edu
Principal Investigator: Lisa Haddad, MD, MS,MPH
Atlanta Women's Center
Recruiting
Atlanta, Georgia, United States, 30342
Contact: Lisa Haddad, MD, MS, MPH 404-778-1385 lisa.haddad@emory.edu
Principal Investigator: Lisa Haddad, MD, MS, MPH 收起 <<
United States, Oregon
... 展开 >>
Oregon Health & Science University
Portland, Oregon, United States, 97239
Dominican Republic
Asociación Dominicana Pro Bienestar de la Familia, Inc. (PROFAMILIA)
Santo Domingo, Dominican Republic 收起 <<
Korea, Republic of
... 展开 >>
Department of Obstetrics and Gynecology, University of Ulsan College of Medicine, Asan Medical Center
Seoul, Korea, Republic of, 138-736 收起 <<
Kenya
... 展开 >> Kisumu East Research Care and Training Program
Kisumu, Kenya
South Africa
Madibeng Centre for Research
Brits, South Africa
Emavundleni Research Centre
Cape Town, South Africa
MatCH Research Unit Commercial City
Durban, South Africa
Effective Care Research Unit (ECRU) Frere Maternity Hospital
East London, South Africa, 5201
Wits Reproductive Health and HIV Institute (WRHI)
Johannesburg, South Africa
Aurum Klerksdorp Gavin Churchyard Legacy Centre
Klerksdorp, South Africa, 2570
QM ladysmith
Ladysmith, South Africa
MatCH Research Unit Edendale
Pietermaritzburg, South Africa
Setshaba Research Centre
Soshanguve, South Africa
Swaziland
FLAS/ICAP Clinic 1& Clinic 2
Manzini, Swaziland
Zambia
University Teaching Hospital, Lusaka, Zambia
Lusaka, Zambia 收起 <<
Estrogen Receptor-negative Bre... 展开 >>ast Cancer
Progesterone Receptor-negative Breast Cancer
Recurrent Breast Cancer
Stage IV Breast Cancer 收起 <<
Phase 2
Completed
-
United States, Alabama
... 展开 >>
University of Alabama at Birmingham
Birmingham, Alabama, United States, 35294
United States, California
University of California, San Francisco Comprehensive Cancer Center
San Francisco, California, United States, 94115
United States, Indiana
Indiana University Melvin and Bren Simon Cancer Center
Indianapolis, Indiana, United States, 46202
United States, Massachusetts
Dana-Farber Cancer Institute
Boston, Massachusetts, United States, 02115
United States, North Carolina
University of North Carolina, Lineberger Comprehensive Cancer Center
Chapel Hill, North Carolina, United States, 27599
Duke University Comprehensive Cancer Center
Durham, North Carolina, United States, 27710
United States, Texas
The University of Texas M. D. Anderson Cancer Center
Houston, Texas, United States, 77030 收起 <<
United States, California
... 展开 >>
Pfizer Investigational Site
Los Angeles, California, United States
Pfizer Investigational Site
Palo Alto, California, United States
Pfizer Investigational Site
Torrance, California, United States
United States, Kentucky
Pfizer Investigational Site
Louisville, Kentucky, United States
United States, Maryland
Pfizer Investigational Site
Baltimore, Maryland, United States
United States, Michigan
Pfizer Investigational Site
Detroit, Michigan, United States
United States, New York
Pfizer Investigational Site
Bronx, New York, United States
United States, Ohio
Pfizer Investigational Site
Cleveland, Ohio, United States
Pfizer Investigational Site
Columbus, Ohio, United States
United States, Pennsylvania
Pfizer Investigational Site
Pittsburgh, Pennsylvania, United States
United States, Rhode Island
Pfizer Investigational Site
Providence, Rhode Island, United States
United States, Virginia
Pfizer Investigational Site
Norfolk, Virginia, United States 收起 <<
Korea, Republic of
... 展开 >>
Gangnam CHA medical center
Recruiting
Seoul, Gamnamgu, Korea, Republic of
Contact: seok ju Seong sjseongcheil@yahoo.co.kr 收起 <<
Endometrial Adenocarcinoma
... 展开 >> Endometrial Adenosquamous Carcinoma
Endometrial Endometrioid Adenocarcinoma, Variant With Squamous Differentiation
Recurrent Uterine Corpus Carcinoma
Stage I Uterine Corpus Cancer
Stage II Uterine Corpus Cancer
Stage III Uterine Corpus Cancer
Stage IV Uterine Corpus Cancer 收起 <<
Phase 2
Completed
-
United States, Pennsylvania
... 展开 >>
Gynecologic Oncology Group
Philadelphia, Pennsylvania, United States, 19103 收起 <<
United States, Florida
... 展开 >>
Planned Parenthood of Southwest and Central Florida
Fort Myers, Florida, United States, 33919
Planned Parenthood of Southwest and Central Florida
Tampa, Florida, United States, 33617 收起 <<
Botswana
... 展开 >> Gaborone Prevention/Treatment Trials CRS (12701)
Gaborone, Botswana
Kenya
Kenya Medical Research Institute/Center for Disease Control (KEMRI/CDC) CRS (31460)
Kisumu, Kenya, 40100
South Africa
Durban Adult HIV CRS (11201)
Durban, South Africa, 4013 SF
Univ. of Witwatersrand CRS (11101)
Johannesburg, South Africa
Zimbabwe
UZ-Parirenyatwa CRS (30313)
Harare, Zimbabwe 收起 <<
United States, Virginia
... 展开 >>
Clinical Research Center, Dept. of Obstetrics & Gynegology, Eastern Virginia Medical School
Norfolk, Virginia, United States, 23507 收起 <<
Brazil
... 展开 >> Universidade Estadual de Campinas (UNICAMP)
CAmpinas, Brazil
Chile
Instituto Chileno De Medicina Reproductiva (ICMER)
Santiago, Chile
Dominican Republic
Asociación Dominicana Pro Bienestar de la Familia, Inc. (PROFAMILIA)
Santo Domingo, Dominican Republic 收起 <<
United States, California
... 展开 >>
University of Southern California LA (5048)
Los Angeles, California, United States, 90033
United States, District of Columbia
Children's National Medical Center Washington DC NICHD CRS (5015)
Washington, District of Columbia, United States, 20010
Washington Hospital Center NICHD CRS (5023)
Washington, District of Columbia, United States, 20010
United States, Florida
South Florida Childrens Diagnostic & Treatment Cen (5055)
Ft. Lauderdale, Florida, United States, 33316
United States, Illinois
Northwestern University CRS (2701)
Chicago, Illinois, United States, 60611
Rush University Cook County Hospital Chicago NICHD CRS (5083)
Chicago, Illinois, United States, 60612
United States, Louisiana
Tulane University New Orleans NICHD CRS (5095)
New Orleans, Louisiana, United States, 70112
United States, New York
Univ. of Rochester ACTG CRS (1101)
Rochester, New York, United States, 14642
SUNY Stony Brook NICHD CRS (5040)
Stony Brook, New York, United States, 11794
United States, North Carolina
Unc Aids Crs (3201)
Chapel Hill, North Carolina, United States, 27516
United States, Ohio
Univ. of Cincinnati CRS
Cincinnati, Ohio, United States, 45267-0405
Univ. of Cincinnati CRS (2401)
Cincinnati, Ohio, United States, 45267
United States, Washington
University of Washington AIDS CRS (1401)
Seattle, Washington, United States, 98104
Puerto Rico
San Juan Hospital PR NICHD CRS (5031)
San Juan, Puerto Rico, 00936 收起 <<
United States, New Jersey
... 展开 >>
Planned Parenthood of Central and Greater Northern New Jersey
Morristown, New Jersey, United States, 07960
United States, Texas
Planned Parenthood Gulf Coast
Houston, Texas, United States, 77023 收起 <<
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