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/ Medroxyprogesterone acetate

醋酸甲羟孕酮酯 /Medroxyprogesterone acetate {[allProObj[0].p_purity_real_show]}

货号：A306697 同义名： 醋酸甲羟孕酮 / Medroxyprogesterone 17-acetate;Farlutin

Medroxyprogesterone acetate, the acetate form of medroxyprogesterone which is a progesterone receptor agonist and a synthetic variant of the human hormone progesterone

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There will be a HazMat fee per item when shipping a dangerous goods. The HazMat fee will be charged to your UPS/DHL/FedEx collect account or added to the invoice unless the package is shipped via Ground service. Ship by air in Excepted Quantity (each bottle), which is up to 1g/1mL for class 6.1 packing group I or II, and up to 25g/25ml for all other HazMat items.

Type HazMat fee for 500 gram (Estimated)
Excepted Quantity USD 0.00
Limited Quantity USD 15-60
Inaccessible (Haz class 6.1), Domestic USD 80+
Inaccessible (Haz class 6.1), International USD 150+
Accessible (Haz class 3, 4, 5 or 8), Domestic USD 100+
Accessible (Haz class 3, 4, 5 or 8), International USD 200+
Medroxyprogesterone acetate 化学结构 CAS号：71-58-9
Medroxyprogesterone acetate 化学结构
CAS号：71-58-9
Medroxyprogesterone acetate 3D分子结构
CAS号：71-58-9
Medroxyprogesterone acetate 化学结构 CAS号：71-58-9
Medroxyprogesterone acetate 3D分子结构 CAS号：71-58-9
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Medroxyprogesterone acetate 纯度/质量文件 产品仅供科研

货号：A306697 标准纯度： {[allProObj[0].p_purity_real_show]}
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Medroxyprogesterone acetate 生物活性

描述 Progesterone Receptor (PGR) is a member or the steroid receptor superfamily. It mediates the physiological effects of progesterone, which plays a central role in reproductive events associated with the establishment and maintenance of pregnancy. Progesterone Receptor is involved in the regulation of eukaryotic gene expression and affect cellular proliferation and differentiation in target tissues. Depending on the isoform, progesterone receptor functions as transcriptional activator or repressor. The glucocorticoid receptor (GR) has a dual mode of action: as a transcription factor that binds to glucocorticoid response elements (GRE), both for nuclear and mitochondrial DNA, and as a modulator of other transcription factors. The glucocorticoid receptor affects inflammatory responses, cellular proliferation and differentiation in target tissues. The glucocorticoid receptor is involved in chromatin remodeling, plays a role in rapid mRNA degradation. The glucocorticoid receptor could also act as a coactivator for STAT5-dependent transcription upon growth hormone stimulation. Medroxyprogesterone acetate is a progestin, a synthetic variant of the human hormone progesterone. Medroxyprogesterone acetate acts as a ligand that binds to progesterone receptor. Reports also suggested that Medroxyprogesterone acetate also binds the glucocorticoid receptor. The details were that Medroxyprogesterone acetate dose dependently increased α-ENaC promoter-driven luciferase activity in M-1 cells, indicating that Medroxyprogesterone acetate regulates α-ENaC in a progesterone receptor-independent manner. Moreover, when tested in HT29 cells, Medroxyprogesterone acetate could only stimulate α-ENaC-driven reporter activity when glucocorticoid receptor was coexpressed[3]. According to another report, thyroid cancer KTC-2 cells incubated with 10-1000 nM Medroxyprogesterone acetate for 2 days showed decreased secretion and mRNA expression of IL-6 and PTHrP in a dose-dependent manner. The finding that KTC-2 cells express glucocorticoid receptor but not progesterone receptor suggested that the effect of Medroxyprogesterone acetate was mediated by glucocorticoid receptor[4]. In a rabbit model of flank wounds, Medroxyprogesterone administrated i.m. at the dose of 35 mg/kg daily prolonged the latent phase of wound healing, slowed the rate and decreased the total amount of contracture[5]. According to a published study evaluating the mnemonic and neurobiological effects of Medroxyprogesterone acetate in surgically menopausal rats, Medroxyprogesterone acetate was given at the low dose of 14 mg or the high dose of 21 mg via implanted Alzet osmotic pumps, which slowly released the agent in vivo. The results were that both doses of Medroxyprogesterone acetate impaired learning. High dose of Medroxyprogesterone acetate impaired delayed memory retention and exacerbated overnight forgetting. Medroxyprogesterone acetate treatment also significantly decreased GAD levels in the hippocampus and significantly increased GAD levels in the entorhinal cort[6].

Medroxyprogesterone acetate 动物研究

Dose Beagle bitches: 0.2 mg/kg - 75 mg/kg[3] (i.m.) Macaque: 1.5 mg/kg[4] (i.m.)
Administration i.m.

Medroxyprogesterone acetate 临床研究

NCT号 适应症或疾病 临床期 招募状态 预计完成时间 地点
NCT03196492 - Recruiting June 14, 2019 United States, Maryland ... 展开 >> Johns Hopkins Hospital Recruiting Baltimore, Maryland, United States, 21205 Contact: Okonkwo 收起 <<
NCT00000897 HIV Infections Not Applicable Completed - United States, California ... 展开 >> San Francisco AIDS Clinic / San Francisco Gen Hosp San Francisco, California, United States, 941102859 United States, Florida Univ of Florida Health Science Ctr / Pediatrics Jacksonville, Florida, United States, 32209 United States, New York Children's Hosp at Albany Med Ctr Albany, New York, United States, 12208 SUNY / Erie County Med Ctr at Buffalo Buffalo, New York, United States, 14215 United States, North Carolina Univ of North Carolina Chapel Hill, North Carolina, United States, 275997215 United States, Washington Univ of Washington Seattle, Washington, United States, 98104 收起 <<
NCT00370019 Premature Ovarian Failure Phase 2 Withdrawn - United States, Maryland ... 展开 >> National Institutes of Health Clinical Center, 9000 Rockville Pike Bethesda, Maryland, United States, 20892 收起 <<

Medroxyprogesterone acetate 参考文献

[1]Ciriza I, Carrero P, et al. Reduced metabolites mediate neuroprotective effects of progesterone in the adult rat hippocampus. The synthetic progestin medroxyprogesterone acetate (Provera) is not neuroprotective. J Neurobiol. 2006 Aug;66(9):916-28.

[2]Kurebayashi J, Otsuki T, et al. Medroxyprogesterone acetate decreases secretion of interleukin-6 and parathyroid hormone-related protein in a new anaplastic thyroid cancer cell line, KTC-2. Thyroid. 2003 Mar;13(3):249-58.

[3]Thomas CP, Liu KZ, Vats HS. Medroxyprogesterone acetate binds the glucocorticoid receptor to stimulate alpha-ENaC and sgk1 expression in renal collecting duct epithelia. Am J Physiol Renal Physiol. 2006 Feb;290(2):F306-12. doi: 10.1152/ajprenal.00062.2005. Epub 2005 Sep 27. PMID: 16189295.

[4]Kurebayashi J, Otsuki T, Tanaka K, Yamamoto Y, Moriya T, Sonoo H. Medroxyprogesterone acetate decreases secretion of interleukin-6 and parathyroid hormone-related protein in a new anaplastic thyroid cancer cell line, KTC-2. Thyroid. 2003 Mar;13(3):249-58. doi: 10.1089/105072503321582042. PMID: 12729473.

[5]Lenco W, Mcknight M, Macdonald AS. Effects of cortisone acetate, methylprednisolone and medroxyprogesterone on wound contracture and epithelization in rabbits. Ann Surg. 1975 Jan;181(1):67-73. doi: 10.1097/00000658-197501000-00015. PMID: 1119869; PMCID: PMC1343717.

[6]Braden BB, Talboom JS, Crain ID, Simard AR, Lukas RJ, Prokai L, Scheldrup MR, Bowman BL, Bimonte-Nelson HA. Medroxyprogesterone acetate impairs memory and alters the GABAergic system in aged surgically menopausal rats. Neurobiol Learn Mem. 2010 Mar;93(3):444-53. doi: 10.1016/j.nlm.2010.01.002. Epub 2010 Jan 13. PMID: 20074654; PMCID: PMC3397202.

Medroxyprogesterone acetate 实验方案

计算器
存储液制备 1mg 5mg 10mg

1 mM

5 mM

10 mM

2.59mL

0.52mL

0.26mL

12.94mL

2.59mL

1.29mL

25.87mL

5.17mL

2.59mL

Medroxyprogesterone acetate 技术信息

CAS号71-58-9
分子式C24H34O4
分子量 386.524
别名 醋酸甲羟孕酮 ;Medroxyprogesterone 17-acetate;Farlutin;U-8839;NSC 21171;NSC-26386;MPA
运输蓝冰
存储条件

液体 -20°C:3-6个月-80°C:12个月

粉末 Sealed in dry,2-8°C
溶解度

DMSO: 9 mg/mL(23.28 mM)，配合低频超声助溶，注意：DMSO长时间开封后，会吸水并导致溶解能力下降，请避免使用长期开封的DMSO

无水乙醇: 6 mg/mL(15.52 mM)，配合低频超声，并水浴加热至45℃助溶，注意：无水乙醇开封后，易挥发，也会吸收空气中的水分，导致溶解能力下降，请避免使用开封较久的乙醇
动物实验配方

IP 2% DMSO+2% Tween80+30% PEG300+water 0.5 mg/mL clear

PO 0.5% CMC-Na 35 mg/mL suspension

Tags: Medroxyprogesterone | 71-58-9 | Medroxyprogesterone 17-acetate | Farlutin | Progesterone Receptor Agonist | Vitamin D Related/Nuclear Receptor | Immunology/Inflammation | Metabolic Enzyme/Protease | Progesterone Receptor | Androgen Receptor | Glucocorticoid Receptor | Endogenous Metabolite | 仅供科研使用 | AmBeed-信号通路专用抑制剂 | Medroxyprogesterone acetate 纯度/质量文件 | Medroxyprogesterone acetate 生物活性 | Medroxyprogesterone acetate 动物研究 | Medroxyprogesterone acetate 临床数据 | Medroxyprogesterone acetate 参考文献 | Medroxyprogesterone acetate 实验方案 | Medroxyprogesterone acetate 技术信息

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