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甲环素磺基水杨酸盐 /Meclocycline Sulfosalicylate Salt {[allProObj[0].p_purity_real_show]}

货号:A173465 同义名: 磺基水杨酸甲氯环素

Meclocycline Sulfosalicylate Salt is a tetracycline antibiotic with broad-spectrum antibacterial activities, preventing skin bacterial infections such as acne vulgaris[1].

Meclocycline Sulfosalicylate Salt 化学结构 CAS号:73816-42-9
Meclocycline Sulfosalicylate Salt 化学结构
CAS号:73816-42-9
Meclocycline Sulfosalicylate Salt 3D分子结构
CAS号:73816-42-9
Meclocycline Sulfosalicylate Salt 化学结构 CAS号:73816-42-9
Meclocycline Sulfosalicylate Salt 3D分子结构 CAS号:73816-42-9
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Meclocycline Sulfosalicylate Salt 纯度/质量文件 产品仅供科研

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Meclocycline Sulfosalicylate Salt 生物活性

描述 Meclocycline sulfosalicylate is bacteriostatic and inhibits bacterial protein synthesis by binding to the 30S ribosomal subunit, thereby preventing the addition of amino acids to the growing peptide chain. Meclocycline Sulfosalicylate is a tetracycline antibiotic with broad-spectrum antibacterial activities, preventing skin bacterial infections such as acne vulgaris[1]. Meclocycline is used topically (i.e. for skin infections) as it is totally insoluble in water and may damage kidney and liver if given systemically[2]. Contrary to meclocycline, flunoxaprofen does not possess bactericidal and bacteriostatic properties. Contrary to meclocycline, flunoxaprofen induces a precocious increase of Döderlein bacillus, necessary for a definitive normalization and to limit the possibility of relapses[3]. Meclocycline can produce significant protection of C. elegans from delayed death. Four of the compounds were tested in an ex vivo mouse heart ischemia/reperfusion model and two, meclocycline and 3-amino-1,2,4-triazole, significantly reduced infarction size[4].

Meclocycline Sulfosalicylate Salt 参考文献

[1]Knutson DD, Swinyer LJ, Smoot WH. Meclocycline sulfosalicylate. Topical antibiotic agent for the treatment of acne vulgaris. Cutis. 1981 Feb;27(2):203-4, 208-10

[2]Grio R, Zaccheo F, Marchino GL, Macchioni S, Rustichelli S, Piacentino R, Coppola C. Attività antibatterica della meclociclina (Mecloderm) nelle vaginiti aspecifiche. Studio su 262 casi [Antibacterial activity of meclocycline (Mecloderm) in non-specific vaginitis. Study of 262 cases]. Minerva Ginecol. 1986 Mar;38(3):163-5. Italian

[3]Facchini V, Rispoli G, Dubini F, Bignami P, Sacchi C. Attività di flunoxaprofene per uso topico nelle vaginiti aspecifiche. Confronto con meclociclina solfosalicilato [Activity of topical flunoxaprofen in nonspecific vaginitis. Comparison with meclocycline sulfosalicylate]. Minerva Ginecol. 1989 Dec;41(12):609-14. Italian

[4]Sun CL, Zhang H, Liu M, Wang W, Crowder CM. A screen for protective drugs against delayed hypoxic injury. PLoS One. 2017 Apr 20;12(4):e0176061

Meclocycline Sulfosalicylate Salt 实验方案

计算器
存储液制备 1mg 5mg 10mg

1 mM

5 mM

10 mM

1.44mL

0.29mL

0.14mL

7.19mL

1.44mL

0.72mL

14.39mL

2.88mL

1.44mL

Meclocycline Sulfosalicylate Salt 技术信息

CAS号73816-42-9
分子式C29H27ClN2O14S
分子量 695.048
别名 磺基水杨酸甲氯环素
运输蓝冰
存储条件

液体 -20°C:3-6个月-80°C:12个月

粉末 Inert atmosphere,2-8°C

溶解度

DMSO: 250 mg/mL(359.69 mM),配合低频超声助溶,注意:DMSO长时间开封后,会吸水并导致溶解能力下降,请避免使用长期开封的DMSO

动物实验配方
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