产品说明书
Meclocycline Sulfosalicylate Salt
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同义名 : | 磺基水杨酸甲氯环素 |
| CAS号 : | 73816-42-9 | |
| 货号 : | A173465 | |
| 分子式 : | C29H27ClN2O14S | |
| 纯度 : | 98% | |
| 分子量 : | 695.048 | |
| MDL号 : | MFCD00082372 | |
| 存储条件： |
粉末 Inert atmosphere,2-8°C 液体 -20°C:3-6个月-80°C:12个月 |
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| 溶解度 : |
DMSO: 250 mg/mL(359.69 mM)，配合低频超声助溶，注意：DMSO长时间开封后，会吸水并导致溶解能力下降，请避免使用长期开封的DMSO |
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| 动物实验配方： |
| 生物活性 | |||
|---|---|---|---|
| 描述 | Meclocycline sulfosalicylate is bacteriostatic and inhibits bacterial protein synthesis by binding to the 30S ribosomal subunit, thereby preventing the addition of amino acids to the growing peptide chain. Meclocycline Sulfosalicylate is a tetracycline antibiotic with broad-spectrum antibacterial activities, preventing skin bacterial infections such as acne vulgaris[1]. Meclocycline is used topically (i.e. for skin infections) as it is totally insoluble in water and may damage kidney and liver if given systemically[2]. Contrary to meclocycline, flunoxaprofen does not possess bactericidal and bacteriostatic properties. Contrary to meclocycline, flunoxaprofen induces a precocious increase of Döderlein bacillus, necessary for a definitive normalization and to limit the possibility of relapses[3]. Meclocycline can produce significant protection of C. elegans from delayed death. Four of the compounds were tested in an ex vivo mouse heart ischemia/reperfusion model and two, meclocycline and 3-amino-1,2,4-triazole, significantly reduced infarction size[4]. | ||
| 实验方案 | |||
|---|---|---|---|
| 1mg | 5mg | 10mg | |
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1 mM 5 mM 10 mM |
1.44mL 0.29mL 0.14mL |
7.19mL 1.44mL 0.72mL |
14.39mL 2.88mL 1.44mL |
| 参考文献 |
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