Mafenide Acetate

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Chemical Structure| 13009-99-9 同义名 : 醋酸马芬尼特
CAS号 : 13009-99-9
货号 : A151118
分子式 : C9H14N2O4S
纯度 : 98%
分子量 : 246.28
MDL号 : MFCD00072089
存储条件：

Pure form Keep in dark place,Inert atmosphere,Room temperature

In solvent -20°C:3-6个月-80°C:12个月
溶解度 :

DMSO: 105 mg/mL(426.34 mM)，配合低频超声助溶，注意：DMSO长时间开封后，会吸水并导致溶解能力下降，请避免使用长期开封的DMSO

H2O: 100 mg/mL(406.04 mM)
动物实验配方：
生物活性
靶点

  • Carbonic Anhydrase
描述 Mafenide acetate is an effective but costly antimicrobial solution used for burn wounds[3]. Hydrofiber saturated with mafenide acetate, whether stored on a dry well plate or nonsterile porcine skin, consistently possessed sustained antimicrobial activity as demonstrated by zones of inhibition greater than 2 mm to both S. aureus and P. aeruginosa[4]. In wounds treated with mafenide acetate, epithelialization occurred by day 7 in 72% of cases and in 84% by day 21. 52% of the mafenide acetate treated wounds showed reparative activity with inflammatory changes by day 7[5]. Mafenide acetate and amphotericin B did not seem to persistently meet the toxicity and efficacy balance as consistently as Dakin's solution[6].
临床研究
NCT号 适应症或疾病 临床期 招募状态 预计完成时间 地点
NCT02099240 Osteomyelitis Early Phase 1 Recruiting September 2019 United States, Kentucky ... 展开 >> University of Louisville Recruiting Louisville, Kentucky, United States, 40202 Contact: Julio A Ramirez, MD    502-852-1148    jarami01@louisville.edu    Contact: David Seligson, MD    502-852-0923    d0seli01@louisville.edu    Sub-Investigator: Forest Arnold, DO          Sub-Investigator: Timothy Wiemkwn, PhD          Sub-Investigator: Robert Kelley, PhD          Sub-Investigator: James Summersgill, PhD          Sub-Investigator: Ruth Carrico, PhD          Sub-Investigator: Julie Harting, PharmD          Sub-Investigator: Paula Peyrani, MD          Principal Investigator: David Seligson, MD          Sub-Investigator: Craig Roberts, MD          Principal Investigator: Julio Ramirez, MD 收起 <<
NCT00675922 Burn Phase 2 Phase 3 Terminated(Data inconclusive.) - United States, Texas ... 展开 >> University of Texas Medical Branch Galveston, Texas, United States, 77555 收起 <<
NCT00586729 - Completed - -
实验方案
1mg 5mg 10mg

1 mM

5 mM

10 mM

4.06mL

0.81mL

0.41mL

20.30mL

4.06mL

2.03mL

40.60mL

8.12mL

4.06mL
参考文献

[1]Siuda JF, Cihonski CD. New compounds: carbamate derivatives of mafenide (homosulfanilamide). J Pharm Sci, 1972. 61(11): p. 1856-7.

[2]Haynes BW Jr. Mafenide acetate in burn treatment. N Engl J Med. 1971 Jun 10;284(23):1324.

[3]Afshari A, Nguyen L, Kahn SA, Montgomery AC, Shinha T, Stratton C, Summitt B. The Effective Duration of Antimicrobial Activity of Mafenide Acetate After Reconstitution. J Burn Care Res. 2018 Aug 17;39(5):736-738. doi: 10.1093/jbcr/irx029. PMID: 29931082.

[4]Kahn SA, Afshari A, Nguyen L, Shinha T, Huff T, Montgomery AC, Stratton C, Summitt B. Hydrofiber Dressing Saturated With Mafenide Acetate Extends the Duration of Antimicrobial Activity. J Burn Care Res. 2017 Jul/Aug;38(4):e704-e707. doi: 10.1097/BCR.0000000000000455. PMID: 27775984.

[5]Maghsoudi H, Salehi F, Khosrowshahi MK, Baghaei M, Nasirzadeh M, Shams R. Comparison between topical honey and mafenide acetate in treatment of burn wounds. Ann Burns Fire Disasters. 2011 Sep 30;24(3):132-7. PMID: 22396671; PMCID: PMC3293229.

[6]Barsoumian A, Sanchez CJ, Mende K, Tully CC, Beckius ML, Akers KS, Wenke JC, Murray CK. In vitro toxicity and activity of Dakin's solution, mafenide acetate, and amphotericin B on filamentous fungi and human cells. J Orthop Trauma. 2013 Aug;27(8):428-36. doi: 10.1097/BOT.0b013e3182830bf9. PMID: 23287750.