ML406 is a small molecule probe with anti-tubercular activity via MtbbioA (DAPA synthase) enzyme inhibition with IC50 of 30 nM. It can inhibit biotin biosynthesis in mycobacterium tuberculosis.
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Type
HazMat fee for 500 gram (Estimated)
Excepted Quantity
USD 0.00
Limited Quantity
USD 15-60
Inaccessible (Haz class 6.1), Domestic
USD 80+
Inaccessible (Haz class 6.1), International
USD 150+
Accessible (Haz class 3, 4, 5 or 8), Domestic
USD 100+
Accessible (Haz class 3, 4, 5 or 8), International
BioA (7, 8-diaminopelargonic acid (DAPA) synthase) catalyzes the reversible transamination between KAPA and DAPA, the second-to-last step of biotin synthesis in Mycobacterium tuberculosis (TB). ML406 is a small molecule probe that exhibits antituberculous activity by inhibiting BioA with an IC50 of 30 nM. ML406 has an IC50 of 155 nM and an EC50 of 9.3 μM with best cellular activity tested in a TB strain with limited biotin formation relative to wild type confirming mechanism of action[1].
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