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ML406

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Chemical Structure| 774589-47-8 同义名 : -
CAS号 : 774589-47-8
货号 : A789739
分子式 : C20H20N2O4
纯度 : 98+%
分子量 : 352.384
MDL号 : MFCD06004413
存储条件：

粉末 Inert atmosphere,Room Temperature

液体 -20°C:3-6个月-80°C:12个月
溶解度 :

DMSO: 105 mg/mL(297.97 mM)，配合低频超声助溶，注意：DMSO长时间开封后，会吸水并导致溶解能力下降，请避免使用长期开封的DMSO
动物实验配方：
生物活性
描述 BioA (7, 8-diaminopelargonic acid (DAPA) synthase) catalyzes the reversible transamination between KAPA and DAPA, the second-to-last step of biotin synthesis in Mycobacterium tuberculosis (TB). ML406 is a small molecule probe that exhibits antituberculous activity by inhibiting BioA with an IC50 of 30 nM. ML406 has an IC50 of 155 nM and an EC50 of 9.3 μM with best cellular activity tested in a TB strain with limited biotin formation relative to wild type confirming mechanism of action[1].
实验方案
1mg 5mg 10mg

1 mM

5 mM

10 mM

2.84mL

0.57mL

0.28mL

14.19mL

2.84mL

1.42mL

28.38mL

5.68mL

2.84mL
参考文献

[1]Casalena D, et al. Discovery of small molecule probe that shows anti-tubercular activity via Mtb bioA (DAPA synthase) enzyme inhibition