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氯沙坦 /Losartan {[allProObj[0].p_purity_real_show]}

货号:A254713 同义名: 洛沙坦 / DuP-753

Losartan是一种血管紧张素 II 受体拮抗剂,以 IC50 为 20 nM 竞争性抑制血管紧张素 II 与 AT1 受体结合。

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There will be a HazMat fee per item when shipping a dangerous goods. The HazMat fee will be charged to your UPS/DHL/FedEx collect account or added to the invoice unless the package is shipped via Ground service. Ship by air in Excepted Quantity (each bottle), which is up to 1g/1mL for class 6.1 packing group I or II, and up to 25g/25ml for all other HazMat items.

Type HazMat fee for 500 gram (Estimated)
Excepted Quantity USD 0.00
Limited Quantity USD 15-60
Inaccessible (Haz class 6.1), Domestic USD 80+
Inaccessible (Haz class 6.1), International USD 150+
Accessible (Haz class 3, 4, 5 or 8), Domestic USD 100+
Accessible (Haz class 3, 4, 5 or 8), International USD 200+
Losartan 化学结构 CAS号:114798-26-4
Losartan 化学结构
CAS号:114798-26-4
Losartan 3D分子结构
CAS号:114798-26-4
Losartan 化学结构 CAS号:114798-26-4
Losartan 3D分子结构 CAS号:114798-26-4
规格 价格 会员价 库存 数量
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Losartan 纯度/质量文件 产品仅供科研

货号:A254713 标准纯度: {[allProObj[0].p_purity_real_show]}
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Losartan 生物活性

靶点
  • AT1 receptor

    AT1 receptor, IC50:20 nM

描述 Losartan, a small-molecule angiotensin II type 1 receptor antagonist used to treat hypertension[3]. The concentration that inhibits 50% of the binding of angiotensin II (IC50) is 20 nM[4]. In vitro, losartan effectively limited the fibrotic potential of RDEB fibroblasts, as measured by cell contractility[3]. In vivo, Losartan was filtered to a final concentration of 0.6 g/L, providing an estimated daily dose of 40-60 mg/kg/day. Losartan treatment prevented significant retinal ganglion cell loss and significantly lowered blood pressure. Losartan inhibited effects of glaucoma[5].

Losartan 临床研究

NCT号 适应症或疾病 临床期 招募状态 预计完成时间 地点
NCT00447603 Hypertension Phase 3 Terminated(Achieving site read... 展开 >>iness and enrolling the trial within a reasonable time) 收起 << - -
NCT01198249 Essential Hypertension Phase 1 Completed - Korea, Republic of ... 展开 >> Severance Hospital Seoul, Korea, Republic of, 120-752 收起 <<
NCT02183701 Hypertension Phase 3 Completed - -

Losartan 参考文献

[1]Burnier M. Angiotensin II type 1 receptor blockers. Circulation. 2001 Feb 13;103(6):904-12.

[2]Strawn WB, Chappell MC, et al. Inhibition of early atherogenesis by losartan in monkeys with diet-induced hypercholesterolemia. Circulation. 2000 Apr 4;101(13):1586-93.

[3]Nyström A, Thriene K, Mittapalli V, Kern JS, Kiritsi D, Dengjel J, Bruckner-Tuderman L. Losartan ameliorates dystrophic epidermolysis bullosa and uncovers new disease mechanisms. EMBO Mol Med. 2015 Sep;7(9):1211-28. doi: 10.15252/emmm.201505061. PMID: 26194911; PMCID: PMC4568953.

[4]Burnier M. Angiotensin II type 1 receptor blockers. Circulation. 2001 Feb 13;103(6):904-12. doi: 10.1161/01.cir.103.6.904. PMID: 11171802.

[5]Quigley HA, Pitha IF, Welsbie DS, Nguyen C, Steinhart MR, Nguyen TD, Pease ME, Oglesby EN, Berlinicke CA, Mitchell KL, Kim J, Jefferys JJ, Kimball EC. Losartan Treatment Protects Retinal Ganglion Cells and Alters Scleral Remodeling in Experimental Glaucoma. PLoS One. 2015 Oct 27;10(10):e0141137. doi: 10.1371/journal.pone.0141137. PMID: 26505191; PMCID: PMC4624713.

Losartan 实验方案

计算器
存储液制备 1mg 5mg 10mg

1 mM

5 mM

10 mM

2.36mL

0.47mL

0.24mL

11.82mL

2.36mL

1.18mL

23.65mL

4.73mL

2.36mL

Losartan 技术信息

CAS号114798-26-4
分子式C22H23ClN6O
分子量 422.911
别名 洛沙坦 ;DuP-753
运输蓝冰
存储条件

In solvent -20°C:3-6个月-80°C:12个月

Pure form Inert atmosphere,2-8°C

溶解方案

DMSO: 105 mg/mL(248.28 mM),注意:DMSO长时间开封后,会吸水并导致溶解能力下降,请避免使用长期开封的DMSO

请根据您的动物给药指南选择适当的溶解方案。
以下溶解方案都请先按照体外实验的方式配制澄清的储备液,再依次添加助溶剂:
——为保证实验结果的可靠性,澄清的储备液可以根据储存条件,适当保存;体内实验的工作液,建议现用现配,当天使用; 以下溶剂前显示的百分比是指该溶剂在终溶液中的体积占比;如在配制过程中出现沉淀、析出现象,可以通过加热和/或超声的方式助溶
方案一
方案二
动物实验配方
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