Lisinopri dihydrate is angiotensin-converting enzyme inhibitor, used in treatment of hypertension, congestive heart failure, and heart attacks. Lisinopril is the only ACE inhibitor that exhibits a linear dose-response curve. Lisinopril may be used to treat hypertension and symptomatic congestive heart failure, to improve survival in certain individuals following myocardial infarction, and to prevent progression of renal disease in hypertensive patients with diabetes mellitus and microalbuminuria or overt nephropathy[3]. In all concentrations (25, 75 and 250 mg/l drinking water), lisinopril significantly increased PRA (plasma renin) and decreased ACE activities. Arterial blood pressure was decreased only in the group receiving high lisinopril concentration (Controls 119+/-10.27, Ld3 98+/-5.4 mm Hg)[4]. Systolic blood pressure (SBP) was normal in Wistar rats, SHR (spontaneously hypertensive rats) expressed hypertension and lisinopril normalized the SBP. Lisinopril normalized the increase in SBP and partly reversed the alterations of anxiety-like behaviour in SHR[5].
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