货号:A117961 同义名: 赖诺普利二水合物 / MK-521 dihydrate
Lisinopril is angiotensin-converting enzyme inhibitor, used in treatment of hypertension, congestive heart failure, and heart attacks.
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描述 | Lisinopri dihydrate is angiotensin-converting enzyme inhibitor, used in treatment of hypertension, congestive heart failure, and heart attacks. Lisinopril is the only ACE inhibitor that exhibits a linear dose-response curve. Lisinopril may be used to treat hypertension and symptomatic congestive heart failure, to improve survival in certain individuals following myocardial infarction, and to prevent progression of renal disease in hypertensive patients with diabetes mellitus and microalbuminuria or overt nephropathy[3]. In all concentrations (25, 75 and 250 mg/l drinking water), lisinopril significantly increased PRA (plasma renin) and decreased ACE activities. Arterial blood pressure was decreased only in the group receiving high lisinopril concentration (Controls 119+/-10.27, Ld3 98+/-5.4 mm Hg)[4]. Systolic blood pressure (SBP) was normal in Wistar rats, SHR (spontaneously hypertensive rats) expressed hypertension and lisinopril normalized the SBP. Lisinopril normalized the increase in SBP and partly reversed the alterations of anxiety-like behaviour in SHR[5]. |
NCT号 | 适应症或疾病 | 临床期 | 招募状态 | 预计完成时间 | 地点 |
NCT01936012 | Healthy | Not Applicable | Completed | - | Indonesia ... 展开 >> PT Equilab International Jakarta, Indonesia, 12430 收起 << |
计算器 | ||||
存储液制备 | 1mg | 5mg | 10mg | |
1 mM 5 mM 10 mM |
2.26mL 0.45mL 0.23mL |
11.32mL 2.26mL 1.13mL |
22.65mL 4.53mL 2.26mL |
CAS号 | 83915-83-7 |
分子式 | C21H35N3O7 |
分子量 | 441.519 |
别名 | 赖诺普利二水合物 ;MK-521 dihydrate |
运输 | 蓝冰 |
存储条件 |
粉末 Keep in dark place,Inert atmosphere,2-8°C 液体 -20°C:3-6个月-80°C:12个月 |
溶解度 |
H2O: 20 mg/mL(45.3 mM),配合低频超声助溶 |
动物实验配方 |