Liothyronin Sodium a synthetic form of the levorotatory isomer of the naturally occurring thyroid hormone triiodothyronine, used to treat hypothyroidism.
Liothyronine Sodium is the sodium salt form of liothyronine, a synthetic form of the levorotatory isomer of the naturally occurring thyroid hormone triiodothyronine (T3). Liothyronine (Sodium) is an active form of thyroid hormone, which binds to β1 thyroid hormone receptor (TRβ1), and activates its activity. Liothyronine (T3, 100 nM) stimulates the proliferation of hepatocarcinema cells in which TRβ1 is overexpressed[3]. High T(3) (triiodothyronine) levels induce a low TRalpha1:TRalpha2 ratio which could protect the cell from excessive T(3)-induced gene expression[4]. Expression of a mutant receptor with impaired triiodothyronine (T(3)) binding and dominant negative activity affected cerebellar development and motor performance. TRs are also involved in adult brain function. TRalpha1 deletion, or expression of a dominant negative mutant receptor, induces consistent behavioral changes in adult mice, leading to severe anxiety and morphological changes in the hippocampus[5].
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