产品说明书
Liothyronine sodium
 |
同义名 : | Triiodothyronine sodium;3,3',5-Triiodo-L-thyronine sodium;Cytomel;T3 sodium |
| CAS号 : | 55-06-1 | |
| 货号 : | A103275 | |
| 分子式 : | C15H11I3NNaO4 | |
| 纯度 : | 95% | |
| 分子量 : | 672.96 | |
| MDL号 : | MFCD00002594 | |
| 存储条件： |
粉末 Keep in dark place,Inert atmosphere,Room temperature 液体 -20°C:3-6个月-80°C:12个月 |
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| 溶解度 : |
DMSO: 4 mg/mL(5.94 mM)，配合低频超声，并水浴加热至45℃助溶，注意：DMSO长时间开封后，会吸水并导致溶解能力下降，请避免使用长期开封的DMSO 0.1 M NaOH: 10 mg/mL(14.86 mM)，配合低频超声，并调节pH至11 |
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| 动物实验配方： |
| 生物活性 | |||
|---|---|---|---|
| 描述 | Liothyronine Sodium is the sodium salt form of liothyronine, a synthetic form of the levorotatory isomer of the naturally occurring thyroid hormone triiodothyronine (T3). Liothyronine (Sodium) is an active form of thyroid hormone, which binds to β1 thyroid hormone receptor (TRβ1), and activates its activity. Liothyronine (T3, 100 nM) stimulates the proliferation of hepatocarcinema cells in which TRβ1 is overexpressed[3]. High T(3) (triiodothyronine) levels induce a low TRalpha1:TRalpha2 ratio which could protect the cell from excessive T(3)-induced gene expression[4]. Expression of a mutant receptor with impaired triiodothyronine (T(3)) binding and dominant negative activity affected cerebellar development and motor performance. TRs are also involved in adult brain function. TRalpha1 deletion, or expression of a dominant negative mutant receptor, induces consistent behavioral changes in adult mice, leading to severe anxiety and morphological changes in the hippocampus[5]. | ||
| 实验方案 | |||
|---|---|---|---|
| 1mg | 5mg | 10mg | |
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1 mM 5 mM 10 mM |
1.49mL 0.30mL 0.15mL |
7.43mL 1.49mL 0.74mL |
14.86mL 2.97mL 1.49mL |
| 参考文献 |
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