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描述 | LJ001 is a versatile and orally active antiviral agent known for its broad-spectrum activity. It operates by binding to viral membranes, effectively inhibiting infections such as TGEV (transmissible gastroenteritis virus) and PDCoV (porcine deltacoronavirus), and reducing the expression of their respective N-proteins[1].[2]. |
体内研究 | In vivo, LJ001 demonstrates no toxicity in mice following oral gavage or intraperitoneal administration daily for 7 days at doses of 20 and 50 mg/kg[2]. |
体外研究 | With a CC50 value of 146.4 μM for ST cells, LJ001 exhibits minimal cytotoxicity over 24 hours, even at concentrations as high as 200 μM[1]. At a concentration of 12.5 µM, LJ001 suppresses both TGEV and PDCoV infections and their gene mRNA expression in ST cells across various time points[1]. Additionally, LJ001's antiviral efficacy extends to inhibiting the entry and spread of multiple enveloped viruses, including HIV, HCV, influenza, Ebola, arenaviruses, and poxviruses[1]. |
计算器 | ||||
存储液制备 | 1mg | 5mg | 10mg | |
1 mM 5 mM 10 mM |
3.05mL 0.61mL 0.31mL |
15.27mL 3.05mL 1.53mL |
30.54mL 6.11mL 3.05mL |
CAS号 | 851305-26-5 |
分子式 | C17H13NO2S2 |
分子量 | 327.421 |
别名 | |
运输 | 蓝冰 |
存储条件 |
粉末 Inert atmosphere,2-8°C 液体 -20°C:3-6个月-80°C:12个月 |
溶解度 |
DMSO: 105 mg/mL(320.69 mM),配合低频超声,并水浴加热至45℃助溶,注意:DMSO长时间开封后,会吸水并导致溶解能力下降,请避免使用长期开封的DMSO |
动物实验配方 |