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LJ001 {[allProObj[0].p_purity_real_show]}

货号:A1483473 Ambeed 开学季,买赠积分,赢豪礼

LJ001是一种广谱的抗病毒分子,能通过与病毒膜结合来发挥抗病毒活性,抑制多种病毒的感染,包括 TGEV 和 PDCoV,表现出强效的抗病毒潜力。

LJ001 化学结构 CAS号:851305-26-5
LJ001 化学结构
CAS号:851305-26-5
LJ001 3D分子结构
CAS号:851305-26-5
LJ001 化学结构 CAS号:851305-26-5
LJ001 3D分子结构 CAS号:851305-26-5
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LJ001 纯度/质量文件 产品仅供科研

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LJ001 生物活性

描述 LJ001 is a versatile and orally active antiviral agent known for its broad-spectrum activity. It operates by binding to viral membranes, effectively inhibiting infections such as TGEV (transmissible gastroenteritis virus) and PDCoV (porcine deltacoronavirus), and reducing the expression of their respective N-proteins[1].[2].
体内研究

In vivo, LJ001 demonstrates no toxicity in mice following oral gavage or intraperitoneal administration daily for 7 days at doses of 20 and 50 mg/kg[2].

体外研究

With a CC50 value of 146.4 μM for ST cells, LJ001 exhibits minimal cytotoxicity over 24 hours, even at concentrations as high as 200 μM[1].

At a concentration of 12.5 µM, LJ001 suppresses both TGEV and PDCoV infections and their gene mRNA expression in ST cells across various time points[1].

Additionally, LJ001's antiviral efficacy extends to inhibiting the entry and spread of multiple enveloped viruses, including HIV, HCV, influenza, Ebola, arenaviruses, and poxviruses[1].

LJ001 参考文献

[1]Zhang Y, et al. Rhodanine derivative LJ001 inhibits TGEV and PDCoV replication in vitro. Virus Res. 2020 Nov;289:198167.

[2]Wolf MC, et al. A broad-spectrum antiviral targeting entry of enveloped viruses. Proc Natl Acad Sci U S A. 2010 Feb 16;107(7):3157-62.

LJ001 实验方案

计算器
存储液制备 1mg 5mg 10mg

1 mM

5 mM

10 mM

3.05mL

0.61mL

0.31mL

15.27mL

3.05mL

1.53mL

30.54mL

6.11mL

3.05mL

LJ001 技术信息

CAS号851305-26-5
分子式C17H13NO2S2
分子量 327.421
别名
运输蓝冰
存储条件

粉末 Inert atmosphere,2-8°C

液体 -20°C:3-6个月-80°C:12个月

溶解度

DMSO: 105 mg/mL(320.69 mM),配合低频超声,并水浴加热至45℃助溶,注意:DMSO长时间开封后,会吸水并导致溶解能力下降,请避免使用长期开封的DMSO

动物实验配方
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