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首页 / 抑制剂/激动剂 / 蛋白质酪氨酸激酶 / c-Fms / Ki20227

Ki20227 {[allProObj[0].p_purity_real_show]}

货号：A691021 Ambeed 开学季，买赠积分，赢豪礼

Ki-20227 is a highly selective c-Fms tyrosine kinase (CSF1R) inhibitor with IC50 value of 2 nM, displaying 6 fold and > 100 fold selectivity over VEGFR2 (IC50=12 nM) and c-Kit/PDGFRβ (IC50=451/217 nM), respectively.

Ki20227 化学结构 CAS号：623142-96-1
Ki20227 化学结构
CAS号：623142-96-1
Ki20227 3D分子结构
CAS号：623142-96-1
Ki20227 化学结构 CAS号：623142-96-1
Ki20227 3D分子结构 CAS号：623142-96-1
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Ki20227 纯度/质量文件 产品仅供科研

货号：A691021 标准纯度： {[allProObj[0].p_purity_real_show]}
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Ki20227 生物活性

描述 It is found that macrophage colony-stimulating factor is important for the differentiation of osteoclasts, thus facilitating it to participate into the development of osteolysis in bone metastatic lesions. Ki20227 is an inhibitor of c-fms tyrosine kinase with IC50 values of 2nM, also showed inhibition against VEGFR2 with IC50 value of 12nM (measured by kinase activity). In cellular study, Ki20227 (>3nM) showed dose-dependent inhibition of M-CSF-dependent c-Fms phosphorylation in RAW264.7 cells cultured in medium supplemented with 0.1% FCS. Also it showed inhibitory activity against M-CSF-dependent and VEGF-dependent cell growth in M-NFS-60 (10-100nM) and HUVEC cells (300-3000nM). As macrophage colony-stimulating factor was important in osteolysis, inhibition of c-Fms kinase by Ki20227 at concentration of 100nM suppressed the development of TRAP-positive osteoclast-like cell formation. Oral administration of 50 mg/kg of Ki20227 daily for 20 days could markedly decrease the osteolytic lesion areas which caused by metastasizing A375 cells in nude rats. Once daily oral treatment with Ki20227 at 20 mg/kg for 28 days significantly reduced the TRAP-positive osteoclastic cells on the bone surface in the primary spongiosa in ovariectomized rats, which suggesting Ki20227 could also suppress TRAP-positive osteoclast-like cell development in a non-tumor-bearing rodent model[1].
作用机制 Not found

Ki20227 动物研究

Dose Nude rat[1] (p.o.): 10 mg/kg - 50 mg/kg
Administration p.o.

Ki20227 实验方案

计算器
存储液制备 1mg 5mg 10mg

1 mM

5 mM

10 mM

2.08mL

0.42mL

0.21mL

10.41mL

2.08mL

1.04mL

20.81mL

4.16mL

2.08mL

Ki20227 技术信息

CAS号623142-96-1
分子式C24H24N4O5S
分子量 480.536
别名
运输蓝冰
存储条件

粉末 Sealed in dry,Store in freezer, under -20°C

液体 -20°C:3-6个月-80°C:12个月
溶解度

DMSO: 60 mg/mL(124.86 mM)，配合低频超声助溶，注意：DMSO长时间开封后，会吸水并导致溶解能力下降，请避免使用长期开封的DMSO
动物实验配方

Tags: Ki20227 | 623142-96-1 | Ki 20227 | Ki-20227 | c-Fm Inhibitor | Protein Tyrosine Kinase/RTK | c-Fms | VEGFR | c-Kit | PDGFR | 仅供科研使用 | AmBeed-信号通路专用抑制剂 | Ki20227 纯度/质量文件 | Ki20227 生物活性 | Ki20227 动物研究 | Ki20227 实验方案 | Ki20227 技术信息

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