KGP94 | Cathepsin L Inhibitor | AmBeed-信号通路专用抑制剂

首页 / / / 组织蛋白酶 / KGP94

KGP94 {[allProObj[0].p_purity_real_show]}

货号：A1678570

KGP94是一种特异性 cathepsin L 抑制剂，IC₅₀ 值为 189 nM，能抑制癌细胞的迁移和侵袭，同时对正常人类细胞的毒性较低 (GI50=26.9µM)，适用于癌症转移研究。

HazMat Fee +

There will be a HazMat fee per item when shipping a dangerous goods. The HazMat fee will be charged to your UPS/DHL/FedEx collect account or added to the invoice unless the package is shipped via Ground service. Ship by air in Excepted Quantity (each bottle), which is up to 1g/1mL for class 6.1 packing group I or II, and up to 25g/25ml for all other HazMat items.

Type	HazMat fee for 500 gram (Estimated)
Excepted Quantity	USD 0.00
Limited Quantity	USD 15-60
Inaccessible (Haz class 6.1), Domestic	USD 80+
Inaccessible (Haz class 6.1), International	USD 150+
Accessible (Haz class 3, 4, 5 or 8), Domestic	USD 100+
Accessible (Haz class 3, 4, 5 or 8), International	USD 200+

KGP94 化学结构
CAS号：1131456-28-4

KGP94 3D分子结构
CAS号：1131456-28-4

规格	价格	会员价	库存	数量
{[ item.pr_size ]}	{[ getRatePrice(item.pr_rmb, 1,1) ]} {[ getRatePrice(item.pr_rmb_sale, 1,1) ]}	{[ getRatePrice(item.pr_rmb, 1,1) ]} {[ getRatePrice(item.pr_rmb,item.pr_rate,1) ]}	{[ getRatePrice(item.pr_rmb, 1,1) ]}	{[ getRatePrice(item.pr_rmb_sale, 1,1) ]} {[ getRatePrice(item.pr_rmb,item.pr_rate,item.mem_rate) ]} {[ getRatePrice(item.pr_rmb,1,item.mem_rate) ]}	现货	咨询	- +

购物车0 收藏询单

sales@ambeed.cn tech@ambeed.cn 400-920-2911 产品手册产品订购技术咨询
快速发货顺丰冷链运输，1-2 天到达

品质保证

技术支持

免费溶解

KGP94 纯度/质量文件产品仅供科研

货号：A1678570 标准纯度： {[allProObj[0].p_purity_real_show]} 产品说明书

批次查询：批次纯度: COA SDS NMR HPLC CNMR LC-MS

全球学术期刊中引用的产品: • JACS Au, 2024. Ambeed. [ A148168 ]; • JMC, 2024. Ambeed. [ A187643 ]; • JMC, 2024. Ambeed. [ A341145 , A633512 , A607865 , A167774 ]; • Biomacromolecules, 2024. Ambeed. [ A110759 ]; • Biomacromolecules, 2024. Ambeed. [ A203543 ]; 更多 >

KGP94 生物活性

描述

KGP94 is a selective cathepsin L inhibitor with an IC50 value of 189 nM^[1].KGP94 inhibits migration and invasion of metastatic cancers and shows low cytotoxicity against a variety of human cell lines (GI50=26.9 µM)^[2].At concentrations of 10 µM or 20 µM, acting for 24 hours, KGP94 reduces the expression of markers of macrophage M2 (arginase-1 and CD206) as well as cellular invasion by primary bone marrow-derived macrophages or Raw264.7^[3].At a concentration of 25 μM for 24 hours of treatment, the effects of KGP94 on the invasive capacity of prostate and respiratory cancer cells were 53% and 88%, respectively, and the inhibition of CTSL activity secreted by PC-3ML and MDA-MB-231 was 94% and 92%, respectively^[4].

KGP94 动物研究

Animal study

At a dose of 20 mg/kg, injected intraperitoneally once a day for 3 days, KGP94 showed anti-metastatic and anti-bone resorption efficacy in a bone metastasis model of prostate cancer. Metastatic tumour burden was reduced by 65%, tumour angiogenesis was reduced by 58%, and survival was improved in mice with bone metastases^[5].

KGP94 参考文献

[1]Parker EN, et al. Synthesis and biological evaluation of a water-soluble phosphate prodrug salt and structural analogues of KGP94, a lead inhibitor of cathepsin L. Bioorg Med Chem Lett. 2017 Mar 1. 27(5):1304-1310.

[2]Munikishore R, et al. An efficient and concise synthesis of a selective small molecule non-peptide inhibitor of cathepsin L: KGP94. Bioorg Chem. 2021 Nov. 116:105317.

[3]Dykes SS, et al. Cathepsin L secretion by host and neoplastic cells potentiates invasion. Oncotarget. 2019 Sep 17. 10(53):5560-5568.

[4]Sudhan DR, et al. Cathepsin L inhibition by the small molecule KGP94 suppresses tumor microenvironment enhanced metastasis associated cell functions of prostate and breast cancer cells. Clin Exp Metastasis. 2013 Oct. 30(7):891-902.

[5]Sudhan DR, et al. Cathepsin L inactivation leads to multimodal inhibition of prostate cancer cell dissemination in a preclinical bone metastasis model. Int J Cancer. 2016 Jun 1;138(11):2665-77.

KGP94 实验方案

计算器

存储液制备

1mg

5mg

10mg

1 mM

5 mM

10 mM

2.86mL

0.57mL

0.29mL

14.28mL

2.86mL

1.43mL

28.55mL

5.71mL

2.86mL

KGP94 技术信息

CAS号	1131456-28-4
分子式	C₁₄H₁₂BrN₃OS
分子量	350.234

别名
运输	蓝冰

存储条件

粉末 Keep in dark place,Inert atmosphere,2-8°C

液体 -20°C:3-6个月-80°C:12个月

溶解度

DMSO: 105 mg/mL(299.8 mM)，注意：DMSO长时间开封后，会吸水并导致溶解能力下降，请避免使用长期开封的DMSO

动物实验配方

KGP94 {[allProObj[0].p_purity_real_show]}

KGP94 纯度/质量文件产品仅供科研

全球学术期刊中引用的产品

KGP94 质控信息

KGP94 生物活性

KGP94 动物研究

KGP94 参考文献

KGP94 实验方案

KGP94 技术信息

最近浏览的产品

大规格询价

摩尔计算器

靶点

总药量计算器

工作液计算器

细胞研究

临床研究

确认信息

热门区域

A

B

C

F

G

H

J

L

N

Q

S

T

X

Y

Z

KGP94 {[allProObj[0].p_purity_real_show]}

KGP94 纯度/质量文件 产品仅供科研

全球学术期刊中引用的产品

KGP94 质控信息

KGP94 生物活性

KGP94 动物研究

KGP94 参考文献

KGP94 实验方案

KGP94 技术信息

最近浏览的产品

大规格询价

摩尔计算器

靶点

总药量计算器

工作液计算器

细胞研究

临床研究

确认信息

请登录您的专属账户

热门区域

A

B

C

F

G

H

J

L

N

Q

S

T

X

Y

Z

KGP94 纯度/质量文件产品仅供科研