Jedi2 | Piezo1 Channel Activator | AmBeed-信号通路专用抑制剂

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Jedi2 {[allProObj[0].p_purity_real_show]}

货号：A1235231

Jedi2 is a specific Piezo1 activator with EC50 value of 158μM. It evokes Piezo1-mediated Ca2+ influx.

Jedi2 化学结构
CAS号：651005-90-2

Jedi2 3D分子结构
CAS号：651005-90-2

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Jedi2 纯度/质量文件产品仅供科研

货号：A1235231 标准纯度： {[allProObj[0].p_purity_real_show]} 产品说明书

批次查询：批次纯度: COA SDS NMR HPLC CNMR LC-MS

全球学术期刊中引用的产品: • JACS Au, 2024. Ambeed. [ A148168 ]; • JMC, 2024. Ambeed. [ A187643 ]; • JMC, 2024. Ambeed. [ A341145 , A633512 , A607865 , A167774 ]; • Biomacromolecules, 2024. Ambeed. [ A110759 ]; • Biomacromolecules, 2024. Ambeed. [ A203543 ]; 更多 >

Jedi2 生物活性

描述

Piezo channels are mechanosensitive ion channels. Piezo1 is primarily expressed in nonsensory tissues, whereas Piezo2 is predominantly found in sensory tissues, including dorsal root ganglion (DRG) neurons^[1].Jedi2 is a Piezo1 activator, but not a specific Piezo2 activator. Jedi2 binds to the mouse Piezo1 proteins with a Kd of 2770 mm. Jedi2 evokes Piezo1-mediated Ca2+ influx. Jedi2 (200 μM) specifically elicits dose-dependent responses in mPiezo1-transfected cells, but not in mPiezo2- or vector-transfected cells. Jedi2 (1 mM) causes an increase in Ca2+ in mCherry-positive HEK293T cells transfected with the mPiezo1-mCherry construct, which also responded to Yoda1 (30 μM). Jedi-induced activation of Piezo1 requires the key mechanotransduction components, including the two extracellular loops in the distal blade and the two leucine residues in the proximal end of the beam^[2]. Piezo1 protein was present in endothelium and PVAT of rat aortic and in PVAT of mesenteric artery.The Piezo1 agonists Yoda1 and Jedi2 (1 nM - 10 µM) did not stimulate aortic contraction [max < 10% phenylephrine (PE) 10 µM contraction] or relaxation in tissues + or -PVAT. Depolarizing the aorta by modestly elevated extracellular K+ did not unmask aortic contraction to Yoda1 (max <10% PE 10 µM contraction)^[3].

Jedi2 参考文献

[1] Jueun Roh, Sung-Min Hwang,et al. Functional Expression of Piezo1 in Dorsal Root Ganglion (DRG) Neurons. Int J Mol Sci. 2020 May 28;21(11):3834.

[2] Yanfeng Wang, et al. A lever-like transduction pathway for long-distance chemical- and mechano-gating of the mechanosensitive Piezo1 channel. Nat Commun. 2018 Apr 3;9(1):1300.

[3] Taylor R Miron, Emma D Flood,et al. Identification of Piezo1 channels in perivascular adipose tissue (PVAT) and their potential role in vascular function. Pharmacol Res. 2022 Jan;175:105995.

Jedi2 实验方案

计算器

存储液制备

1mg

5mg

10mg

1 mM

5 mM

10 mM

4.80mL

0.96mL

0.48mL

24.01mL

4.80mL

2.40mL

48.02mL

9.60mL

4.80mL

Jedi2 技术信息

CAS号	651005-90-2
分子式	C₁₀H₈O₃S
分子量	208.234

别名
运输	蓝冰

存储条件

粉末 Keep in dark place,Sealed in dry,2-8°C

液体 -20°C:3-6个月-80°C:12个月

溶解度

DMSO: 50 mg/mL(240.11 mM)，配合低频超声助溶，注意：DMSO长时间开封后，会吸水并导致溶解能力下降，请避免使用长期开封的DMSO

动物实验配方

摩尔计算器

计算溶液所需的质量，体积或浓度。 Ambeed 摩尔浓度计算器基于以下方程式：

浓度 (mol/L) × 体积 (L) × 分子量 (g/mol)=质量 (g)

浓度

体积

分子量

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Jedi2 纯度/质量文件 产品仅供科研

全球学术期刊中引用的产品

Jedi2 质控信息

Jedi2 生物活性

Jedi2 参考文献

Jedi2 实验方案

Jedi2 技术信息

最近浏览的产品

大规格询价

摩尔计算器

靶点

总药量计算器

工作液计算器

细胞研究

临床研究

确认信息

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Jedi2 纯度/质量文件产品仅供科研