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/ Imiquimod

咪喹莫特 /Imiquimod {[allProObj[0].p_purity_real_show]}

货号：A161049 同义名： R 837;S-26308

Imiquimod（R 837）是一种免疫调节剂，作为选择性的Toll样受体7（TLR7）激动剂，体内显示出抗病毒和抗肿瘤效应。它用于外生殖器和会阴疣、癌症和COVID-19的研究。

HazMat Fee +

There will be a HazMat fee per item when shipping a dangerous goods. The HazMat fee will be charged to your UPS/DHL/FedEx collect account or added to the invoice unless the package is shipped via Ground service. Ship by air in Excepted Quantity (each bottle), which is up to 1g/1mL for class 6.1 packing group I or II, and up to 25g/25ml for all other HazMat items.

Type HazMat fee for 500 gram (Estimated)
Excepted Quantity USD 0.00
Limited Quantity USD 15-60
Inaccessible (Haz class 6.1), Domestic USD 80+
Inaccessible (Haz class 6.1), International USD 150+
Accessible (Haz class 3, 4, 5 or 8), Domestic USD 100+
Accessible (Haz class 3, 4, 5 or 8), International USD 200+
Imiquimod 化学结构 CAS号：99011-02-6
Imiquimod 化学结构
CAS号：99011-02-6
Imiquimod 3D分子结构
CAS号：99011-02-6
Imiquimod 化学结构 CAS号：99011-02-6
Imiquimod 3D分子结构 CAS号：99011-02-6
规格 价格 会员价 库存 数量
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Imiquimod 纯度/质量文件 产品仅供科研

货号：A161049 标准纯度： {[allProObj[0].p_purity_real_show]}
批次查询： 批次纯度:

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Imiquimod 生物活性

描述 Toll like receptors (TLR) is a family with ten members that are known to be important for provoking the innate immunity and establishing adaptive immunity[1]. The imiquimod is TLR7 and 8 agonist with EC50 value of 1.5 μM on TLR7[2]. It is effective in treating a variety of primary skin cancers and cutaneous metastases of some malignancies[3].
Imiquimod reduced cell numbers on the DFT1 and DFT2 cells lines in a concentration dependent manner as measured by the WST-8 proliferation assay after incubating with 7.5 - 60 μg/ml of imiquimod for 24 hours. When the cells were incubated with 60 μg/ml of imiquimod for 72 hours, most of cells entered apoptotic pathways and complete apoptosis for all the cells occurred at 120 hours as measured by annexin V and PI staining [4] .
When 30 mg/mouse of imiquimod was applied for seven consecutive days on the back skin of late telogen C57BL/6 mice one day after hair removal, the number of CD45 positive cells increased compared with control group as measure by flow cytometry. The level of IL-6, Cxcl-1, TNF-a, IL23p19 and IL-17a examined by quantitative real-time reverse transcription PCR were induced in the imiquimod treatment group[5].
作用机制 Imiquimod could preferentially bind to TLR7 and to a lesser extent, TLR8[6].

Imiquimod 动物研究

Dose Mice: 1 mg/kg[6] (p.o.) Guinea pig: 5 mg/kg[7] (i.v.); 3 mg/kg[8] (i.p.) Rat: 1 mg/kg - 6 mg/kg[9] (p.o.) rabbit: 0.5 mg/kg - 2 mg/kg[9] (i.v.)
Administration p.o., i.v., i.p.

Imiquimod 临床研究

NCT号 适应症或疾病 临床期 招募状态 预计完成时间 地点
NCT00147771 Scleroderma, Localized Phase 3 Completed - Canada, Ontario ... 展开 >> The Hospital for Sick Children Toronto, Ontario, Canada, M5G 1X8 收起 <<
NCT01795313 Ependymoma Not Applicable Recruiting January 2020 United States, Pennsylvania ... 展开 >> Children's Hospital of Pittsburgh of UPMC Recruiting Pittsburgh, Pennsylvania, United States, 15224 Contact: Mary Petrany, RN    412-692-8047    petranym@upmc.edu 收起 <<
NCT00581425 Basal Cell Carcinoma Phase 4 Completed - United States, Texas ... 展开 >> University of Texas Health Science Center of Houston Dermatology Clinic Houston, Texas, United States, 77030 收起 <<

Imiquimod 参考文献

[1]Kaisho T, Akira S. Toll-like receptor function and signaling. J Allergy Clin Immunol. 2006;117(5):979-87; quiz 988.

[2]Makarenko EV, Kozlovskiĭ IV. [Comparative characteristics of adenosine triphosphatase activity in the erythrocytes of patients with acute and chronic liver diseases, chronic cholecystitis and in HBs antigen carriers]. Ter Arkh. 1987;59(2):98-100.

[3]Schön MP, Schön M. Imiquimod: mode of action. Br J Dermatol. 2007.

[4]Patchett AL, Darby JM, et al. The Immunomodulatory Small Molecule Imiquimod Induces Apoptosis in Devil Facial Tumour Cell Lines. PLoS One. 2016;11(12):e0168068.

[5]Amberg N, Holcmann M, et al. Effects of Depilation Methods on Imiquimod-Induced Skin Inflammation in Mice. J Invest Dermatol. 2017;137(2):528-531.

Imiquimod 实验方案

计算器
存储液制备 1mg 5mg 10mg

1 mM

5 mM

10 mM

4.16mL

0.83mL

0.42mL

20.81mL

4.16mL

2.08mL

41.61mL

8.32mL

4.16mL

Imiquimod 技术信息

CAS号99011-02-6
分子式C14H16N4
分子量 240.304
别名 R 837;S-26308;Beselna.;Vyloma;Zyclara;Imiquimod Brand name: Aldara;TMX 101
运输蓝冰
存储条件

液体 -20°C:3-6个月-80°C:12个月

粉末 Keep in dark place,Inert atmosphere,Store in freezer, under -20°C
溶解度

DMSO: 2 mg/mL(8.32 mM)，配合低频超声，并水浴加热至45℃助溶，注意：DMSO长时间开封后，会吸水并导致溶解能力下降，请避免使用长期开封的DMSO

H2O: 2.5 mg/mL(10.4 mM)，配合低频超声，并调节pH至2
动物实验配方

Tags: Imiquimod | 99011-02-6 | R 837 | R837 | R-837 | TLR7 Agonist | Induced Disease Models Products | Immunology/Inflammation | Autophagy | Anti-infection | Immunology and Inflammatory Disease Models | Skin Disease Models | Toll-like Receptor (TLR) | Autophagy | SARS-CoV | HSV | Psoriasis Models | 仅供科研使用 | AmBeed-信号通路专用抑制剂 | Imiquimod 纯度/质量文件 | Imiquimod 生物活性 | Imiquimod 动物研究 | Imiquimod 临床数据 | Imiquimod 参考文献 | Imiquimod 实验方案 | Imiquimod 技术信息

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