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/ Ibandronate Sodium

伊班膦酸钠 /Ibandronate Sodium {[allProObj[0].p_purity_real_show]}

货号：A612115

Ibandronate sodium is a highly potent nitrogen-containing bisphosphonate used for the treatment of osteoporosis.

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Ibandronate Sodium 化学结构 CAS号：138844-81-2
Ibandronate Sodium 化学结构
CAS号：138844-81-2
Ibandronate Sodium 3D分子结构
CAS号：138844-81-2
Ibandronate Sodium 化学结构 CAS号：138844-81-2
Ibandronate Sodium 3D分子结构 CAS号：138844-81-2
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Ibandronate Sodium 纯度/质量文件 产品仅供科研

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Ibandronate Sodium 生物活性

描述 Ibandronate Sodium is a highly potent nitrogen-containing bisphosphonate used for the treatment of osteoporosis. Low-dose ibandronate (1.25-2 microM) significantly reduced endothelial cell growth, while 2 microM ibandronate also significantly reduced capillary-like tube formation and increased apoptosis of endothelial cells compared to untreated cells. There was no significant difference in activity with doses above 2 microM[3]. Ibandronate (0.5 to 5 mg/day orally or 0.5 to 2 mg every 3 months intravenously) dose-dependently increased bone mineral density, with parallel reductions in the biochemical markers of bone turnover. In preliminary studies in patients with Paget's disease a single intravenous ibandronate dose (2mg) decreased serum alkaline phosphatase levels and urinary markers of bone turnover[4]. Ibandronate effectively inhibits growth of prostate cancer cell lines via inhibition of the farnesyl-IPP-synthase and exhibits synergistic effects with docetaxel[5]. Ibandronate (< 125 mg/kg s.c.) results in a dose dependent increase in bone mineral density (BMD), trabecular bone volume and trabecular number, load to failure (Fmax), and yield load in long bones and vertebrae in ovariectomized rats, and increased trabecular separation in ovariectomized rats is fully prevented by all doses[6].

Ibandronate Sodium 临床研究

NCT号 适应症或疾病 临床期 招募状态 预计完成时间 地点
NCT02731040 - Enrolling by invitation June 30, 2018 -
NCT02520362 - Active, not recruiting May 25, 2020 -
NCT02155595 - Active, not recruiting August 2018 United States, Michigan ... 展开 >> Henry Ford Medical Center, New Center One Detroit, Michigan, United States, 48202 收起 <<

Ibandronate Sodium 参考文献

[1]Epplen R, Stockle M, et al. Differential effects of ibandronate, docetaxel and farnesol treatment alone and in combination on the growth of prostate cancer cell lines. Acta Oncol. 2011 Jan;50(1):127-33.

[2]Morgan C, Jeremiah S, et al. Metronomic administration of ibandronate and its anti-angiogenic effects in vitro. Microvasc Res. 2009 Dec;78(3):453-8.

[3]Morgan C, Jeremiah S, Wagstaff J. Metronomic administration of ibandronate and its anti-angiogenic effects in vitro. Microvasc Res. 2009 Dec;78(3):453-8

[4]Dooley M, Balfour JA. Ibandronate. Drugs. 1999 Jan;57(1):101-8; discussion 109-10

[5]Epplen R, Stöckle M, Engelmann U, Heidenreich A, Ohlmann CH. Differential effects of ibandronate, docetaxel and farnesol treatment alone and in combination on the growth of prostate cancer cell lines. Acta Oncol. 2011 Jan;50(1):127-33

[6]Bauss F, Lalla S, Endele R, Hothorn LA. Effects of treatment with ibandronate on bone mass, architecture, biomechanical properties, and bone concentration of ibandronate in ovariectomized aged rats. J Rheumatol. 2002 Oct;29(10):2200-8

Ibandronate Sodium 实验方案

计算器
存储液制备 1mg 5mg 10mg

1 mM

5 mM

10 mM

2.93mL

0.59mL

0.29mL

14.65mL

2.93mL

1.47mL

29.31mL

5.86mL

2.93mL

Ibandronate Sodium 技术信息

CAS号138844-81-2
分子式C9H22NNaO7P2
分子量 341.211
别名
运输蓝冰
存储条件

液体 -20°C:3-6个月-80°C:12个月

粉末 Keep in dark place,Sealed in dry,2-8°C
溶解度
动物实验配方

Tags: Ibandronate Sodium | Osteoclasts/Bone/Osteogenesis | AmBeed-信号通路专用抑制剂 | Ibandronate Sodium 纯度/质量文件 | Ibandronate Sodium 生物活性 | Ibandronate Sodium 临床数据 | Ibandronate Sodium 参考文献 | Ibandronate Sodium 实验方案 | Ibandronate Sodium 技术信息

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