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描述 | HS38 is a potent, selective, and ATP-competitive inhibitor, targeting death-associated protein kinase 1 (DAPK1) and zipper-interacting protein kinase (ZIPK or DAPK3) with dissociation constants (Kds) of 300 nM and 280 nM, respectively. Additionally, it acts as a PIM3 inhibitor with an IC50 of 200 nM, showing potential for smooth muscle related disorder research[1]. |
体外研究 | HS38 also shows a high affinity for DAPK2, with a Kd of 79 nM, although DAPK2 is not associated with smooth muscle contractility[1]. HS38 effectively decreases relative RLC20 phosphorylation in both basal and sphingosine 1-phosphate (S1P) activated states in human aortic smooth muscle (SM) cells and reduces contractile forces in intact mouse aorta and Ca2+-sensitized rabbit ileum tissue, indicating its impact on muscle relaxation and contractility[1]. |
计算器 | ||||
存储液制备 | 1mg | 5mg | 10mg | |
1 mM 5 mM 10 mM |
2.86mL 0.57mL 0.29mL |
14.29mL 2.86mL 1.43mL |
28.59mL 5.72mL 2.86mL |
CAS号 | 1030203-81-6 |
分子式 | C14H12ClN5O2S |
分子量 | 349.795 |
别名 | |
运输 | 蓝冰 |
存储条件 |
粉末 Sealed in dry,2-8°C 液体 -20°C:3-6个月-80°C:12个月 |
溶解度 |
DMSO: 6 mg/mL(17.15 mM),配合低频超声助溶,注意:DMSO长时间开封后,会吸水并导致溶解能力下降,请避免使用长期开封的DMSO |
动物实验配方 |