H-Se-Met-OH是一种天然氨基酸,是重要的有机硒来源之一。L-SelenoMethionine通过饮食摄入,降低癌症的发生率并诱导癌细胞凋亡。此外,L-SelenoMethionine 还能使谷胱甘肽过氧化物酶的表达增加。
There will be a HazMat fee per item when shipping a dangerous goods. The HazMat fee will be charged to your UPS/DHL/FedEx collect account or added to the invoice unless the package is shipped via Ground service. Ship by air in Excepted Quantity (each bottle), which is up to 1g/1mL for class 6.1 packing group I or II, and up to 25g/25ml for all other HazMat items.
Type | HazMat fee for 500 gram (Estimated) |
Excepted Quantity | USD 0.00 |
Limited Quantity | USD 15-60 |
Inaccessible (Haz class 6.1), Domestic | USD 80+ |
Inaccessible (Haz class 6.1), International | USD 150+ |
Accessible (Haz class 3, 4, 5 or 8), Domestic | USD 100+ |
Accessible (Haz class 3, 4, 5 or 8), International | USD 200+ |
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描述 | L-SelenoMethionine, an L-isomer of Selenomethionine, is a major natural food-form of selenium[1]. SeMet (l-selenomethionine) caused an increase in arrest in the G2-M phase of the cell cycle selectively in cancer cells. Inhibition of cancer cell growth by SeMet was associated with phosphorylation of P-Tyr15-p34/cdc2, which caused growth arrest in the G2-M phase. SeMet selectively induces apoptosis in cancer but not primary cells of the human prostate[2]. The mechanism by which SeM prevents radiation-induced transformation in vitro may involve the suppression of the expression of genes associated with stress-related signaling and certain cell adhesion events[3]. SERENA study demonstrated a beneficial effect of L-Se-Met (L-selenomethionine) supplementation on autoantibody titer during pregnancy and on postpartum thyroiditis recurrence[4]. |
计算器 | ||||
存储液制备 | ![]() |
1mg | 5mg | 10mg |
1 mM 5 mM 10 mM |
5.10mL 1.02mL 0.51mL |
25.50mL 5.10mL 2.55mL |
50.99mL 10.20mL 5.10mL |
CAS号 | 3211-76-5 |
分子式 | C5H11NO2Se |
分子量 | 196.11 |
SMILES Code | O=C(O)[C@@H](N)CC[Se]C |
MDL No. | MFCD00037210 |
别名 | SEM; SeMet; L-SelenoMethionine |
运输 | 蓝冰 |
InChI Key | RJFAYQIBOAGBLC-BYPYZUCNSA-N |
Pubchem ID | 105024 |
存储条件 |
In solvent -20°C:3-6个月-80°C:12个月 Pure form Keep in dark place, inert atmosphere, store in freezer, under -20°C |
溶解方案 |
DMSO: 1 mg/mL(5.1 mM),配合低频超声助溶,注意:DMSO长时间开封后,会吸水并导致溶解能力下降,请避免使用长期开封的DMSO H2O: 14 mg/mL(71.39 mM),配合低频超声助溶 |