H-Se-Met-OH
产品说明书
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同义名 : | SEM; SeMet; L-SelenoMethionine |
| CAS号 : | 3211-76-5 | |
| 货号 : | A355129 | |
| 分子式 : | C5H11NO2Se | |
| 纯度 : | 98% | |
| 分子量 : | 196.106 | |
| MDL号 : | MFCD00037210 | |
| 存储条件： |
Pure form Keep in dark place, inert atmosphere, store in freezer, under -20°C In solvent -20°C:3-6个月-80°C:12个月 |
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| 溶解度 : |
DMSO: 1 mg/mL(5.1 mM)，配合低频超声助溶，注意：DMSO长时间开封后，会吸水并导致溶解能力下降，请避免使用长期开封的DMSO H2O: 14 mg/mL(71.39 mM)，配合低频超声助溶 |
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| 动物实验配方： |
| 生物活性 | |||
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| 描述 | L-SelenoMethionine, an L-isomer of Selenomethionine, is a major natural food-form of selenium[1]. SeMet (l-selenomethionine) caused an increase in arrest in the G2-M phase of the cell cycle selectively in cancer cells. Inhibition of cancer cell growth by SeMet was associated with phosphorylation of P-Tyr15-p34/cdc2, which caused growth arrest in the G2-M phase. SeMet selectively induces apoptosis in cancer but not primary cells of the human prostate[2]. The mechanism by which SeM prevents radiation-induced transformation in vitro may involve the suppression of the expression of genes associated with stress-related signaling and certain cell adhesion events[3]. SERENA study demonstrated a beneficial effect of L-Se-Met (L-selenomethionine) supplementation on autoantibody titer during pregnancy and on postpartum thyroiditis recurrence[4]. | ||
| 实验方案 | |||
|---|---|---|---|
| 1mg | 5mg | 10mg | |
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1 mM 5 mM 10 mM |
5.10mL 1.02mL 0.51mL |
25.50mL 5.10mL 2.55mL |
50.99mL 10.20mL 5.10mL |
| 参考文献 |
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