Glycerol is frequently added to polyacrylamide gels in electrophoresis to prevent the dissociation of nucleosomes and other protein-DNA complexes. The inclusion of glycerol in the gels generally results in fractionation based primarily on particle mass and charge. The glycerol concentration during electrophoresis significantly influences the separation characteristics of the gels[1]. Glycerol, an inevitable by-product of oils and fats processing, has been extensively studied for its fermentative metabolism, particularly within Enterobacteriaceae species such as Citrobacter freundii and Klebsiella pneumoniae. Its conversion through anaerobic fermentation into higher-value products is seen as a viable economic strategy for enhancing the profitability of the biofuels industry, given the abundance and low cost of glycerol from biodiesel production[2].
体内研究
In rat models, glycerol can induce acute renal failure. This condition, whether triggered by glycerol or uranyl nitrate, affects the hepato-biliary transport of certain drugs, alters drug distribution within the central nervous system, and impacts the activity of various hepatic microsomal enzymes[3].
体外研究
Glycerol is frequently added to polyacrylamide gels in electrophoresis to prevent the dissociation of nucleosomes and other protein-DNA complexes. The inclusion of glycerol in the gels generally results in fractionation based primarily on particle mass and charge. The glycerol concentration during electrophoresis significantly influences the separation characteristics of the gels[1].
Glycerol, an inevitable by-product of oils and fats processing, has been extensively studied for its fermentative metabolism, particularly within Enterobacteriaceae species such as Citrobacter freundii and Klebsiella pneumoniae. Its conversion through anaerobic fermentation into higher-value products is seen as a viable economic strategy for enhancing the profitability of the biofuels industry, given the abundance and low cost of glycerol from biodiesel production[2].
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