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胰高血糖素TFA /Glucagon (1-29), bovine, human, porcine {[allProObj[0].p_purity_real_show]}

货号：A605325 同义名： 胰高血糖素 / Porcine glucagon;Glucagon

Glucagon is a peptide hormone, exhibits therapeutic potential for metabolic disease.

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Type HazMat fee for 500 gram (Estimated)
Excepted Quantity USD 0.00
Limited Quantity USD 15-60
Inaccessible (Haz class 6.1), Domestic USD 80+
Inaccessible (Haz class 6.1), International USD 150+
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Accessible (Haz class 3, 4, 5 or 8), International USD 200+
Glucagon (1-29), bovine, human, porcine 化学结构 CAS号：16941-32-5
Glucagon (1-29), bovine, human, porcine 化学结构
CAS号：16941-32-5
Glucagon (1-29), bovine, human, porcine 3D分子结构
CAS号：16941-32-5
Glucagon (1-29), bovine, human, porcine 化学结构 CAS号：16941-32-5
Glucagon (1-29), bovine, human, porcine 3D分子结构 CAS号：16941-32-5
规格 价格 会员价 库存 数量
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Glucagon (1-29), bovine, human, porcine 纯度/质量文件 产品仅供科研

货号：A605325 标准纯度： {[allProObj[0].p_purity_real_show]}
批次查询： 批次纯度:

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Glucagon (1-29), bovine, human, porcine 生物活性

描述 Glucagon, encoded by proglucagon gene and manufactured by the α cells in the pancreatic islets, stimulates glucose production through glycogenolysis and gluconeogenesis. Glucagon and insulin work together to maintain euglycemia and glucose transport to the tissues. The blood glucose levels determine whether glucagon or insulin is activated or inhibited. Low plasma glucose stimulates glucagon secretion which in turn promotes hepatic gluconeogenesis and glycogenolysis to normalize plasma glucose levels. Administration of glucagon increases glucose levels via gluconeogenesis and glycogenolysis in fasted or fed animals and in humans. But excessive glucagon might result from a tumor in the tail or the body of the pancreas, potentially leading to the glucagonoma syndrome, comprising weight loss, necrolytic migratory erythema (NME), diabetes, and mucosal abnormalities including stomatitis, cheilitis, and glossitis [3].
作用机制 Glucagon binds to its membrane-bound receptor, a seven-pass transmembrane G-protein-coupled receptor [3].

Glucagon (1-29), bovine, human, porcine 临床研究

NCT号 适应症或疾病 临床期 招募状态 预计完成时间 地点
NCT00655603 Type 2 Diabetes Mellitus Not Applicable Unknown September 2009 -
NCT00515801 Diabetes Mellitus, Type 1 Phase 2 Phase 3 Completed - Switzerland ... 展开 >> University Hospital Basel Basel, Switzerland, 4031 收起 <<
NCT03667053 Hypoglycemia Phase 3 Recruiting August 1, 2019 United States, California ... 展开 >> AMCR Institute, Inc Recruiting Escondido, California, United States, 92025 Contact: Tim Bailey 收起 <<

Glucagon (1-29), bovine, human, porcine 参考文献

[1]Finan B, Clemmensen C, et al. Chemical Hybridization of Glucagon and Thyroid Hormone Optimizes Therapeutic Impact for Metabolic Disease. Cell. 2016 Oct 20;167(3):843-857.e14.

[2]Kristensen PL, Pedersen-Bjergaard U, et al. Impact of the TCF7L2 genotype on risk of hypoglycaemia and glucagon secretion during hypoglycaemia. Endocr Connect. 2016 Nov;5(6):53-60. Epub 2016 Oct 10.

[3] Venugopal SK, Sankar P, Jialal I. Physiology, Glucagon. 2020 Oct 27. In: StatPearls [Internet]. Treasure Island (FL): StatPearls Publishing; 2020 Jan–.

Glucagon (1-29), bovine, human, porcine 实验方案

计算器
存储液制备 1mg 5mg 10mg

1 mM

5 mM

10 mM

0.29mL

0.06mL

0.03mL

1.44mL

0.29mL

0.14mL

2.87mL

0.57mL

0.29mL

Glucagon (1-29), bovine, human, porcine 技术信息

CAS号16941-32-5
分子式C153H225N43O49S
分子量 3482.747
别名 胰高血糖素 ;Porcine glucagon;Glucagon;Glucagon HCl
运输蓝冰
存储条件

液体 -20°C:3-6个月-80°C:12个月

粉末 Keep in dark place,Sealed in dry,2-8°C
溶解度

DMSO: 2 mg/mL(0.57 mM)，配合低频超声助溶，注意：DMSO长时间开封后，会吸水并导致溶解能力下降，请避免使用长期开封的DMSO

H2O: 6.5 mg/mL(1.87 mM)，配合低频超声，并调节pH至3
动物实验配方

Tags: Glucagon (1-29), bovine, human, porcine | Porcine glucagon;Glucagon;Glucagon HCl | 胰高血糖素 | Glucagon Receptor | AmBeed-信号通路专用抑制剂 | Glucagon (1-29), bovine, human, porcine 纯度/质量文件 | Glucagon (1-29), bovine, human, porcine 生物活性 | Glucagon (1-29), bovine, human, porcine 临床数据 | Glucagon (1-29), bovine, human, porcine 参考文献 | Glucagon (1-29), bovine, human, porcine 实验方案 | Glucagon (1-29), bovine, human, porcine 技术信息

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