Gentamicin sulfate, an aminoglycoside antibiotic, inhibits the growth of both gram-positive and gram-negative bacteria and to inhibit several strains of mycoplasma in tissue culture. It inhibits DNase I with an IC50 of 0.57 mM[3]. Gentamicin is a more effective in vitro bacterial inhibitor than combined penicillinstreptomycin, is nontoxic to tissue culture monolayers, and does not inhibit virus replication[4]. Gentamicin sulfate (GS) is used usually as intravenous or intramuscular solution because of its poor oral bioavailability[5]. Ototoxicity was greater when gentamicin was administered during their diurnal rest than during nocturnal activity. A dosing paradigm may be used to deliver a lower therapeutic antimicrobial concentration during the nighttime rest period when the studied adverse effects are of highest risk[6].
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