产品说明书
Gentamicin sulfate
 |
同义名 : | NSC-82261;SCH9724 |
| CAS号 : | 1405-41-0 | |
| 货号 : | A917368 | |
| 分子式 : | H2O4S.xUnspecified | |
| 纯度 : | USP26,≥590IU/mg | |
| 分子量 : | 0 | |
| MDL号 : | MFCD00270181 | |
| 存储条件： |
粉末 Inert atmosphere,2-8°C 液体 -20°C:3-6个月-80°C:12个月 |
|
| 溶解度 : |
H2O: 30 mg/mL |
|
| 动物实验配方： |
| 生物活性 | |||
|---|---|---|---|
| 描述 | Gentamicin sulfate, an aminoglycoside antibiotic, inhibits the growth of both gram-positive and gram-negative bacteria and to inhibit several strains of mycoplasma in tissue culture. It inhibits DNase I with an IC50 of 0.57 mM[3]. Gentamicin is a more effective in vitro bacterial inhibitor than combined penicillinstreptomycin, is nontoxic to tissue culture monolayers, and does not inhibit virus replication[4]. Gentamicin sulfate (GS) is used usually as intravenous or intramuscular solution because of its poor oral bioavailability[5]. Ototoxicity was greater when gentamicin was administered during their diurnal rest than during nocturnal activity. A dosing paradigm may be used to deliver a lower therapeutic antimicrobial concentration during the nighttime rest period when the studied adverse effects are of highest risk[6]. | ||
| 参考文献 |
|---|